Registration Dossier
Registration Dossier
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EC number: 247-094-1 | CAS number: 25550-51-0
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
Please refer to IUCLID Section 13. - Reason / purpose for cross-reference:
- read-across source
- Transformation products:
- yes
- No.:
- #1
- Key result
- pH:
- 4
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0.008 s-1
- DT50:
- 1.43 min
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 7
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0.006 s-1
- DT50:
- 1.9 min
- Type:
- (pseudo-)first order (= half-life)
- Key result
- pH:
- 9
- Temp.:
- 20 °C
- Hydrolysis rate constant:
- 0.009 s-1
- DT50:
- 1.27 min
- Type:
- (pseudo-)first order (= half-life)
Reference
Description of key information
Hydrolysis: Half life -
at ph 4: 1.43 minutes at 20 deg C; 2.04 minutes at 30 deg C and 0.692 minutes at 50 deg C.
at ph 7: 1.90 minutes at 20 deg C; 1.26 minutes at 30 deg C and 0.327 minutes at 50 deg C.
at ph 9: 1.27 minutes at 20 deg C; 1.18 minutes at 30 deg C and 0.233 minutes at 50 deg C.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 1.9 min
- at the temperature of:
- 20 °C
Additional information
Hydrolysis as a function of pH was assessed from read across approach data available for the structural analogue 4-MHHPA as similar chemical and environmental fate properties were assumed. Hydrolysis as a function of pH has been investigated in accordance with OECD/EU test methods. 4-MHHPA was found to be highly unstable in aqueous media at pH 4, 7 and 9 and temperatures of 20, 30 and 50 °C.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
