Registration Dossier
Registration Dossier
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EC number: 247-094-1 | CAS number: 25550-51-0
Endpoint summary
Administrative data
Description of key information
Additional information
No data was available for MHHPA. Instead a read across approach was used, assessing data of 4- MHHPA, as these substance was considered to show similar ecotoxicological properties.
Acute immobilisation to Daphnia magna, algal growth inhibition to unicellular freshwater green alga and acute toxicity to fish have been investigated. In Daphnia and fish no effects were observed at a concentration of 100 mg/L. In algae, 4 –MHHPA was found to inhibit the growth after 72 hours exposure, EC50-values with 95 % confidence intervals for inhibition of specific growth rate (ErC50) and yield (EyC50) being 135 (127 – 143) mg/L and 81.3 (72.7 – 89.8) mg/L, respectively. In accordance with ECHA guidance on information requirements and chemical safety assessment, Chapter R.7b: Endpoint specific guidance, the ErC50 endpoint is used in DNEL derivation. This is because use of values based on biomass cannot be applied to an analysis of results from a system in exponential growth without logarithmic transformation.
Toxicity to microorganisms has been investigated in an activated sludge respiration inhibition test according to OECD test methods. 4 –MHHPA caused a concentration related inhibition ranging from 14% at 58 mg/L to 99% at 1000 mg/L. The EC50 was 219 (189 – 248) mg/L with concentrations of 95.3 mg/L and below causing less that 20% inhibition and regarded as not toxic to microorganisms of a municipal sewage treatment plant. EC10, estimated from reported EC20, EC50 and EC80 values, was approximately 70 mg/L. Effects or pH on inhibition were examined and found to be the major factor in determining effects, a concentration of 1000 mg/L causing <20% inhibition when pH was adjusted back to neutral.
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