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Toxicological information

Genetic toxicity: in vivo

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Administrative data

Endpoint:
genetic toxicity in vivo, other
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data

Data source

Reference
Reference Type:
review article or handbook
Title:
IARC Monograph vol 93
Year:
2006
Bibliographic source:
IARC publication
Report date:
2006

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Carbon black
EC Number:
215-609-9
EC Name:
Carbon black
Cas Number:
1333-86-4
Molecular formula:
C
IUPAC Name:
Carbon black
Test material form:
solid: granular

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: dust
Duration of treatment / exposure:
12 weeks

Results and discussion

Any other information on results incl. tables

ln rats exposed to carbon black by inhalation, hprt mutant frequency was elevated in type II celIs folIowing a 12-week exposure.

 

In two of five studies, carbon black induced an increase in DNA adducts in the peripheral lung tissue of rats after inhalation exposure

Applicant's summary and conclusion

Conclusions:
Most of assays for mutagenicity were negative for carbon black