Registration Dossier
Registration Dossier
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EC number: 215-609-9 | CAS number: 1333-86-4
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- other: not reported
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- The effect of carbon black ingestion on 1,2-dimethylhydrazine- induced colon carcinogenesis in rats and mice.
- Author:
- Pence, B.C. & Buddingh, F.
- Year:
- 1 985
- Bibliographic source:
- The effect of carbon black ingestion on 1,2-dimethylhydrazine- induced colon carcinogenesis in rats and mice. Toxicol. Lett., 25, 273-277
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 452 (Chronic Toxicity Studies)
- Deviations:
- not specified
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Carbon black
- EC Number:
- 215-609-9
- EC Name:
- Carbon black
- Cas Number:
- 1333-86-4
- Molecular formula:
- C
- IUPAC Name:
- carbon
- Test material form:
- solid: pellets
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: feed
- Duration of treatment / exposure:
- 2 years
- No. of animals per sex per dose:
- 31 and 28 animals with doses 0 and 2.05 g/kg diet
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Mortality:
- no mortality observed
- Details on results:
- Survival was not affected.
No increase in tumour incidence was observed
Effect levels
open allclose all
- Key result
- Dose descriptor:
- dose level: 2.05 g/kg
- Effect level:
- >= 2 050 - <= 2 050 mg/kg diet
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- clinical signs
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Key result
- Dose descriptor:
- dose level: 2.05 G/kg diet
- Effect level:
- >= 2 050 - <= 2 050 mg/kg diet
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- mortality
- Remarks on result:
- not determinable due to absence of adverse toxic effects
Target system / organ toxicity
- Key result
- Critical effects observed:
- no
- System:
- gastrointestinal tract
Any other information on results incl. tables
Survival was not affected. No increase in tumour incidence was observed
Applicant's summary and conclusion
- Conclusions:
- Carbon black is not classified as target organ toxicant via oral exposure route.
- Executive summary:
Survival of mices is not affected by repeated oral absorption of carbon black.
No tumour incidence.
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