Registration Dossier
Registration Dossier
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EC number: 215-277-5 | CAS number: 1317-61-9
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: short report - original language Russian
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 976
Materials and methods
- Principles of method if other than guideline:
- Type: reproduction in the course of a chronic toxicity study
Method: application of magnetite as a 50% suspension in sunflower oil - GLP compliance:
- no
- Type of method:
- in vivo
Test material
- Reference substance name:
- Triiron tetraoxide
- EC Number:
- 215-277-5
- EC Name:
- Triiron tetraoxide
- Cas Number:
- 1317-61-9
- Molecular formula:
- Fe3O4
- IUPAC Name:
- Iron oxide
- Details on test material:
- Test substance: Magnetite (no data on purity)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: sunflower oil
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 6 weeks
- Frequency of treatment:
- weekly
Doses / concentrations
- Remarks:
- Doses / Concentrations:
20 000 mg/kg
Basis:
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- other: reproduction in the course of a chronic toxicity study
- Effect level:
- > 20 000 other: mg/kg bw/weekly
- Based on:
- test mat.
- Basis for effect level:
- other: No effects of the treatment were detected regarding number and development of offspring
Observed effects
Applicant's summary and conclusion
- Executive summary:
- No effects of the treatment were detected regarding number and development of offspring
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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