Reaction products of bis(4-methylpentan-2-yl)dithiophosphoric acid with phosphorus oxide, propylene oxide and amines, C12-14-alkyl (branched)

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

29 April 2009 - 10 August 2009

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study was performed according to guideline

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Issued by: The Department of Health of the Government of the United Kingdom Inspection date: 19 August 2008

Type of method:

flask method

Water solubility:

ca. 39.5 mg/L

Temp.:

20 °C

pH:

>= 6.2 - <= 6.5

Remarks on result:

other: at a nominal loading rate of 100 mg/L water

Water solubility:

ca. 137.6 mg/L

Temp.:

20 °C

pH:

6.4

Remarks on result:

other: at a nominal loading rate of 1000 mg/L water

Details on results:

The water solubility of the test material is loading rate dependent. At loading concentrations of 100 and 1,000 mg/L, the water solubility is 39.5 mg/L and 137.6 mg/L, respectively, at 20 degrees C

Table 5: Results of Water Solubility Test

Test No.	Loading Rate (mg/L)	Shaking Time at 30^0C (hours)	Equilibration Time at 20^0C (hours)	pH	Water Solubility (mg/L)	Mean (mg/L)
1	103.8	24	24	6.4	* 29.5	39.5
2	100.9	48	24	6.2	38.5
3	100.9	72	24	6.5	40.5
4	1009.8	24	24	6.4	130	137.6
5	1007.1	48	24	6.4	134
6	1018	72	24	6.4	149

* not included in calculation of mean; this sample not fully equilibrated

Conclusions:

Interpretation of results (migrated information): other: The water solubility is loading rate dependent: 39.6 mg/L (at loading rate of 100 mg/L) and 137.6 mg/L (at loading rate of 1 g/L) at 20 degrees C.
The water solubility of the test material is loading rate dependent.

Executive summary:

The water solubility of the test substance was assessed using a shake flask method performed according to EU Method A.6 guidelines and the recommendations in the ECHA Chapter R.7a: Endpoint specific guidance for complex UVCB substances.

 

The study was performed at test substance loading rates of 100 mg/L and 1000 mg/L, with quantitation of the water soluble portion by GPC (gel permeation chromatography). In this study, the solubility of the test material at 20 C was determined to be loading rate dependent: 39.5 mg/L (at loading rate 100 mg/L) and 137.6 mg/L (at loading rate 1000 mg/L).  

 

The chemical identity of the water soluble and insoluble components of the test material could not be determined. The test substance is an incompletely characterized mixture of components (a UVCB). Normal phase chromatography followed by ESI-MS characterization of isolated fractions showed fractions with similar spectral characteristics. The complexity and inability to isolate individual components and the lack of significant diffrences in the spectra of isolated fractions indicates a mixture of components that may be interacting to form complexes that cannot be separated and limits our ability to identify and quantify individual components in the test substance.  

 

Description of key information

The water solubility is loading rate dependent: 39.6 mg/L (at loading rate of 100 mg/L) and 137.6 mg/L (at loading rate of 1 g/L) at 20 degrees C (EU Method A.6).

Key value for chemical safety assessment

Water solubility:

137.6 mg/L

at the temperature of:

20 °C

Additional information

The water solubility of the test substance was assessed using a shake flask method performed according to EU Method A.6 guidelines and the recommendations in the ECHA Chapter R.7a: Endpoint specific guidance for complex UVCB substances.

 

The study was performed at test substance loading rates of 100 mg/L and 1000 mg/L, with quantitation of the water soluble portion by GPC (gel permeation chromatography). In this study, the solubility of the test material at 20 C was determined to be loading rate dependent: 39.5 mg/L (at loading rate 100 mg/L) and 137.6 mg/L (at loading rate 1000 mg/L). 

 

The chemical identity of the water soluble and insoluble components of the test material could not be determined. The test substance is an incompletely characterized mixture of components (a UVCB). Normal phase chromatography followed by ESI-MS characterization of isolated fractions showed fractions with similar spectral characteristics. The complexity and inability to isolate individual components and the lack of significant diffrences in the spectra of isolated fractions indicates a mixture of components that may be interacting to form complexes that cannot be separated and limits our ability to identify and quantify individual components in the test substance.