Registration Dossier
Registration Dossier
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EC number: 627-071-6 | CAS number: 1233873-37-4
Specific investigations: other studies
Administrative data
- Endpoint:
- endocrine system modulation
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: recent study conducted according to reliable in-house protocol
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: according to P. Sohoni and J.P. Sumpter (1998)
- Principles of method if other than guideline:
- The aim of the study was to determine the androgenic and antiandrogenic potential of Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted). The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
- GLP compliance:
- no
- Type of method:
- in vitro
Test material
- Reference substance name:
- 2-[(1Z)-(hydroxyimino)methyl]-4-(2-methylundecyl)phenol
- EC Number:
- 627-071-6
- Cas Number:
- 1233873-37-4
- Molecular formula:
- C19H31NO2
- IUPAC Name:
- 2-[(1Z)-(hydroxyimino)methyl]-4-(2-methylundecyl)phenol
- Details on test material:
- - Name of test material: Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted)
- Physical state: Liquid, highly viscous, golden brown
- Analytical purity: >99%
- Storage condition of test material: Room temperature
Constituent 1
Test animals
- Species:
- other: yeast
Administration / exposure
- Vehicle:
- DMSO
Results and discussion
- Details on results:
- ln this study, the test substance Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted) showed no androgenic activity in comparison to dihydrotestosterone.
ln this study, the test substance Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted) showed no antiandrogenic activity in comparison to hydroxyflutamide.
No cytotoxicity was observed.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
