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EC number: 201-081-7 | CAS number: 78-08-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1993-06-01 to 1993-06-03
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of hydrolysis products in stock solution determined by Total Organic Carbon analysis. The stock solution concentration (464 mg/L equivalent to a test substance concentration of 1145 mg/L) was used as the basis for determining the concentrations in the test media.
- Vehicle:
- no
- Details on test solutions:
- - Method: Test media prepared by dilution of a 1000 mg/L stock solution prepared by mixing for 18 h followed by filtration. TOC concentration of stock solution determined.
- Treatments: Control and nominal test concentrations of 57, 80, 115, 160, 229, 321 and 458 mg/L. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain: Clone 5
- Source: Stock culture
- Age at study initiation (mean and range, SD): <24 h
- Method of breeding: Parthenogenetic reproduction
- Feeding during test: None
ACCLIMATION
- Acclimation conditions (same as test or not): yes
- Type and amount of food: sufficient to be consumed each day leaving no residue
- Feeding frequency: daily - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- none
- Hardness:
- The sum of the Ca2+ and Mg2+ ions was 2.5 mmol
- Test temperature:
- 20 ±1ºC
- pH:
- 7.0 - 7.2
- Dissolved oxygen:
- 6.5 - 8.1 mg/L
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Control and nominal test concentrations of 57, 80, 115, 160, 229, 321 and 458 mg/L.
- Details on test conditions:
- TEST SYSTEM
- Test vessel:
- Type: open
- Material, size, headspace, fill volume: glass cylinder containing 10 ml of test medium
- Aeration: none
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Elendt M4 medium
- Intervals of water quality measurement: end of test
OTHER TEST CONDITIONS
- Photoperiod: Dark
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : Immobilization after 24 and 48 h exposure
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 1.4
STATISTICS
EC50 and confidence interval determined by Probit analysis - Reference substance (positive control):
- yes
- Remarks:
- Potassium dichromate
- Duration:
- 24 h
- Dose descriptor:
- EC50
- Effect conc.:
- 297.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 223.9 - 224.2
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 168.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 126.9 - 224.2
- Details on results:
- - Mortality of control: 0
- Results with reference substance (positive control):
- - EC50: >0.9, <1.9 mg/L
- Reported statistics and error estimates:
- The EC50 value and its 95% confidence interval was calculated by Probit analysis.
- Validity criteria fulfilled:
- yes
- Conclusions:
- Measured data was not available for trieoxy(vinyl)silane (CAS 78-08-0) data was therefore read across from the comparable substance, Trimethoxyvinylesilane (CAS 2768-02-7). A 48-h EC50 value of 168.7 mg/L has been determined for the effects of the test substance on mobility of Daphnia magna. A NOEC was not determined in the test. It is likely that the test organisms were primarily exposed to the hydrolysis products of the substance.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions. No GLP or analysis of exposure media and no description of the test substance.
- Principles of method if other than guideline:
- Not described
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- no data
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Not reported
- Test type:
- not specified
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- Hard water
- Test temperature:
- 23±1ºC
- pH:
- no data
- Dissolved oxygen:
- no data
- Salinity:
- Not applicable
- Nominal and measured concentrations:
- Nominal concentrations: 0(Control), 1, 10 and 100 mg/l
- Details on test conditions:
- TEST SYSTEM
- Test vessel: Beaker
- Type: open
- Material, size, fill volume: Glass, 200 ml with 200 ml of test medium
- Aeration: not reported
- Renewal rate of test solution: not reported
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
- Biomass loading rate: 1 daphnid/20 ml
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: Reconstituted hard water prepared from distilled water.
- Culture medium different from test medium: no
- Intervals of water quality measurement: not reported
OTHER TEST CONDITIONS
- Adjustment of pH: no data
- Photoperiod: 18 h light, 6 h dark
- Light intensity: 600 foot candles
EFFECT PARAMETERS MEASURED: daily mortalities
TEST CONCENTRATIONS
- Spacing factor for test concentrations: 10
- Range finding study: not reported - Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 1 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of control: 5%
- Other adverse effects control: none - Reported statistics and error estimates:
- There were insufficient mortalities in the test to determine an LC50 value. Statistical analysis was not applied to determining a NOEC..
- Validity criteria fulfilled:
- yes
- Conclusions:
- A 48-hour EC50 value of >100 mg/l and NOEC of 1 mg/l have been determined for the effects of the test substance on mobility of Daphnia magna. It is likely that the test organism were primarily exposed to the hydrolysis product of the substance.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- Not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature
- Principles of method if other than guideline:
- Not described
- GLP compliance:
- not specified
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- not specified
- Water media type:
- freshwater
- Dose descriptor:
- EC50
- Effect conc.:
- 360 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- An EC50 value of 360 mg/l has been determined for the effects of the test substance on mobility of Daphnia magna. The result is reported in secondary literature and its reliability cannot be assessed.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- Please refer to overall summary (IUCLID Section 6.1) and attached justification for grouping in IUCLID Section 13.
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 168.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 126.9 - 224.2
- Remarks:
- Hüls AG 1993
- Dose descriptor:
- EC50
- Effect conc.:
- 360 mg/L
- Nominal / measured:
- not specified
- Conc. based on:
- not specified
- Basis for effect:
- mobility
- Remarks on result:
- other: Chandra 1997
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: Dow Corning 1979
Referenceopen allclose all
Table 1. Test results
Nominal test substance concentration (mg/L) | Percentage immobile Daphnia after 24 hours | Percentage immobile Daphnia after 48 hours |
0 (Control) | 0 | 0 |
57 | 5 | 25 |
80 | 5 | 25 |
115 | 5 | 35 |
160 | 0 | 35 |
229 | 25 | 45 |
321 | 55 | 75 |
458 | 90 | 100 |
20% mortality was recorded in the 100 mg/l treatment.
Description of key information
A 48-h EC50 value of 168.7 mg/l (mobility of Daphnia magna, EU Method C.2), RL2
Key value for chemical safety assessment
Additional information
Measured data were not available for the target substance triethoxy(vinyl)silane (CAS 78-08-0), therefore read across from the analogue substance, trimethoxy(vinyl)silane (CAS 2768-02-7) was deemed acceptable for assessment.
According to EU Method C.2 and GLP a 48 h EC50 value of 168.7 mg/l was determined for the effects of the test substance on mobility of Daphnia magna (Hüls AG, 1993a). Further information support that the substance is not toxic to freshwater invertebrates (Chandra, 1997). As the test substance hydrolyses rapidly in water it is likely that the test organisms were exposed predominantly to its hydrolysis products.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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