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EC number: 270-796-4 | CAS number: 68478-17-1 A complex combination of hydrocarbons produced as the residual fraction from the distillation of heavy coker gas oil and vacuum gas oil. It predominantly consists of hydrocarbons having carbon numbers predominantly greater than C13 and boiling above approximately 230°C (446°F).
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
Results of mouse skin painting tests and initiation/promotion assays, together with modified Ames tests, and chemical (PAH) analysis indicate that Heavy Fuel Oil Components, particularly those containing cracked material, are carcinogenic.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 1
- Study duration:
- chronic
- Species:
- mouse
- Quality of whole database:
- Clear, significant increase in histologically diagnosed malignant skin tumours following lifetime treatment with 1% Catalytic Cracked Clarified Oil in toluene.
Justification for classification or non-classification
Positive results in mouse skin painting studies and an initiation/promotion assay, together with supporting modified Ames data and
chemical (PAH) analysis show Cracked Heavy Fuel Oils Components are carcinogenic.
Classification Carcinogenic 1B, H350 is appropriate under the EU CLP Regulation (EC No. 1272/2008).
Additional information
Results from mouse skin painting studies demonstrate that cracked Heavy Fuel Oil Components are clearly carcinogenic.
The dermal carcinogenicity of catalytic cracked clarified oil (0.1%, 1% or 10% in toluene; CAS# 64741 -62 -4) was tested in a key non-guideline GLP-compliant lifetime mouse skin painting study (API, 1989a). The test solutions (50 uL) were applied twice weekly to an area of clipped skin on the dorsum, and the test included appropriate negative (sham, vehicle) and positive (0.01%, 0.05% benzo(a)pyrene) controls. Treatment was for the lifetime of the animals. The test substance elicited skin irritation that was similar in extent and incidence to that seen in the vehicle controls, with an increased incidence of malignant tumours with decreased latency present in the intermediate and high dose groups. A satisfactory response was obtained for the positive controls. The report concluded that catalytic cracked clarified oil was a strong dermal carcinogen.
Results from three skin painting studies on catalytic cracked clarified oil (CAS#64741 -62 -4) demonstrate a clear increase in incidence of malignant tumours (carcinomas) with decreased latency. Concentrations of 5% of the test substance in white oil produced tumors in most of the treated mice,
indicating that catalytic cracked clarified oil is a strong dermal carcinogen (McKee, 1990). Additionally, one study (Bingham, 1980) demonstrated that the uncracked base stock was not carcinogenic whilst the cracked base stock was weakly carcinogenic and all blends containing catalytically cracked clarified oil were carcinogenic in mice.A single initiation/promotion assay also demonstrated that catalytically cracked clarified oil (CAS# 64741 -62 -4) is an initiator (API, 1989b).
Overall it can be concluded that both Straight-run and Cracked Heavy Fuel Oil Components are carcinogenic.
Justification for selection of carcinogenicity via dermal route endpoint:
One of 4 available studies.
Carcinogenicity: via dermal route (target organ): other: skin
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