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EC number: 635-156-4 | CAS number: 109293-98-3
Table 1: Hydrolytic and hydroxylation products of the test item
2-Acetyl nicotinic acid
- Differences between Male and Female Rats:
It appeared that there was no significant difference in absorption, distribution, metabolism and elimination in male and female rats. Administered radiocarbon was partially absorbed in both sexes. The distribution patterns in various tissues and organs were similar between male and female. The metabolic profiles in urine, feces and bile were also similar between sexes. The test item also rapidly eliminated both in male and female.
- Differences between Dose Rates:
There was no significant difference in the percentage absorption between the dose rate of 10 mg/kg bw and 1 000 mg/kg bw.
- Difference between Phenyl and Pyridinyl Labels:
Blood radiocarbon concentrations for the phenyl label were higher than those for the pyridinyl label. For example in Group A (phenyl label) males, blood contained 0.048% of the dose 72 hr after i.v. administration as compared to Group E (pyridinyl label) males with 0.004% of the dose. The association of radiocarbon from the phenyl label may be due to the generation of M2 which has the tendency to conjugate with blood component such as hemoglobin.
- Difference between Single and Multiple Doses:
There was only a slight difference in radiocarbon elimination rate between single and multiple doses. For example the elimination half-life was 5.5 hr for Group B (single dose) male vs. 6.2 hr for Group D (multiple doses) male. Residue levels in tissues for the single dose were slightly lower than the multiple doses. These data showed that the test item had no tendency to bioaccumulate in animal systems.
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