Registration Dossier
Registration Dossier
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EC number: 215-168-2 | CAS number: 1309-37-1
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: 1 low dose level only; limited set of investigations (respiratory tract only)
Data source
Reference
- Reference Type:
- publication
- Title:
- The stathmokinetic and morphological response of hamster respiratory epithelium to intralaryngeal instillations of saline and ferric oxide
- Author:
- Marshall HE, Keenan KP, McDowell EM
- Year:
- 1 987
- Bibliographic source:
- Fundam Appl Toxicol 9, 705-714 (1987)
Materials and methods
- Principles of method if other than guideline:
- weekly repeated intralaryngeal instillation 15 to 20 animals per group
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Diiron trioxide
- EC Number:
- 215-168-2
- EC Name:
- Diiron trioxide
- Cas Number:
- 1309-37-1
- Molecular formula:
- Fe2O3
- IUPAC Name:
- diiron(3+) trioxidandiide
- Reference substance name:
- Iron(III)oxide
- IUPAC Name:
- Iron(III)oxide
- Details on test material:
- Test substance: Fe2O3 (Pfizer Chemical, type R3098R, Lot J5)
Fe2O3; purchased from Pfizer Chemical; no further data
Constituent 1
Constituent 2
Test animals
- Species:
- hamster, Syrian
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intralaryngeal
- Vehicle:
- physiological saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 1, 5, 10, or 15 weeks
- Frequency of treatment:
- once a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
3 mg/animal/dose
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
No difference of mitotic rate on the tracheal and bronchial epithelium but in the bronchioles; bronchioalveolar hyper-
plasia after 5 applications and less prominent after 10 or
15 treatments
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
