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Toxicological information

Repeated dose toxicity: other routes

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Administrative data

Endpoint:
repeated dose toxicity: other route
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1967

Materials and methods

GLP compliance:
no

Test material

Constituent 1
Reference substance name:
dusts and fumes from ferrosilicon furnace
IUPAC Name:
dusts and fumes from ferrosilicon furnace
Details on test material:
- mainly amorphous silicon dioxide and small amounts of quartz (<1%, 3-6%)
- particles (named as P125) were round in shape, and 96% of the particles were less than 0.2 micron.

Test animals

Species:
rat
Strain:
Wistar
Sex:
female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Age at study initiation: 5 to 6 months old
- Weight at study initiation: 180-220 g
- Housing: in cages with a thermostatically controlled temperature
- Diet (e.g. ad libitum): diet was restricted + a supplementary mouse bread ad libidum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-26

Administration / exposure

Route of administration:
other: intra-tracheal
Doses / concentrations
Remarks:
Doses / Concentrations:
40 mg

Results and discussion

Results of examinations

Organ weight findings including organ / body weight ratios:
effects observed, treatment-related
Histopathological findings: non-neoplastic:
effects observed, treatment-related
Details on results:
ORGAN WEIGHTS
The weight of the lungs was significantly higher than in controls, and in animals given titanium oxide or glass wool, at all times of observation, but only at the later observations with regard to the animals given iron silicate and olivine. A parallel development occurred with regard to the collagen content of the lungs following administration of P125.

HISTOPATHOLOGY: NON-NEOPLASTIC
In histological examination, the findings indicated that this type of particle causes a certain fibrillar reaction, but that the progressive tendency may be slight.

Effect levels

Dose descriptor:
NOAEL
Remarks on result:
not determinable
Remarks:
no NOAEL identified

Target system / organ toxicity

Critical effects observed:
not specified

Any other information on results incl. tables

Macroscopic findings showed that administration of atmospheric dust (P125) from the furnace of the ferrosilicon melting works causes a reaction in the experimental animals. Even if the pathological changes did not progress to more advanced stages in the course of the observation period, they were sufficiently pronounced to indicate the presence of reactions in the lungs.

Applicant's summary and conclusion

Executive summary:

In Glømme (1966-67), rats were given intraperitoneally 40 mg of particles containing small quantities of quartz. The particles - named as P125 - were round in shape, and 96% of the particles were less than 0.2 micron. Macroscopic findings showed that the administration of atmospheric dust (P125) from the furnace of the ferrosilicon melting works causes a reaction in the experimental animals. Even if the pathological changes did not progress to more advanced stages in the course of the observation period, they were sufficiently pronounced to indicate the presence of reactions in the lungs. In the histological examination, the findings indicated that this type of particle causes a certain fibrillar reaction, but that the progressive tendency may be slight. The weight of the lungs was significantly higher than in the controls and in animals given titanium oxide or glass wool at all times of observation, but only at the later observations with regard to the animals given iron silicate and olivine. A parallel development occurred with regard to the collagen content of the lungs following the administration of P125.

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