Ferrosilicon - reaction mass of iron and iron disilicide and iron silicide and silicon

Repeated dose toxicity: other routes

Administrative data

Endpoint:

repeated dose toxicity: other route

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1967

Materials and methods

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

dusts and fumes from ferrosilicon furnace

IUPAC Name:

dusts and fumes from ferrosilicon furnace

Details on test material:

- mainly amorphous silicon dioxide and small amounts of quartz (<1%, 3-6%)
- particles (named as P125) were round in shape, and 96% of the particles were less than 0.2 micron.

Test animals

Species:

rat

Strain:

Wistar

Sex:

female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Age at study initiation: 5 to 6 months old
- Weight at study initiation: 180-220 g
- Housing: in cages with a thermostatically controlled temperature
- Diet (e.g. ad libitum): diet was restricted + a supplementary mouse bread ad libidum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22-26

Administration / exposure

Route of administration:

other: intra-tracheal

Doses / concentrations

Remarks:

Doses / Concentrations:
40 mg

Results and discussion

Results of examinations

Organ weight findings including organ / body weight ratios:

effects observed, treatment-related

Histopathological findings: non-neoplastic:

effects observed, treatment-related

Details on results:

ORGAN WEIGHTS
The weight of the lungs was significantly higher than in controls, and in animals given titanium oxide or glass wool, at all times of observation, but only at the later observations with regard to the animals given iron silicate and olivine. A parallel development occurred with regard to the collagen content of the lungs following administration of P125.

HISTOPATHOLOGY: NON-NEOPLASTIC
In histological examination, the findings indicated that this type of particle causes a certain fibrillar reaction, but that the progressive tendency may be slight.

Effect levels

Dose descriptor:

NOAEL

Remarks on result:

not determinable

Remarks:

no NOAEL identified

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Macroscopic findings showed that administration of atmospheric dust (P125) from the furnace of the ferrosilicon melting works causes a reaction in the experimental animals. Even if the pathological changes did not progress to more advanced stages in the course of the observation period, they were sufficiently pronounced to indicate the presence of reactions in the lungs.

Applicant's summary and conclusion

Executive summary:

In Glømme (1966-67), rats were given intraperitoneally 40 mg of particles containing small quantities of quartz. The particles - named as P125 - were round in shape, and 96% of the particles were less than 0.2 micron. Macroscopic findings showed that the administration of atmospheric dust (P125) from the furnace of the ferrosilicon melting works causes a reaction in the experimental animals. Even if the pathological changes did not progress to more advanced stages in the course of the observation period, they were sufficiently pronounced to indicate the presence of reactions in the lungs. In the histological examination, the findings indicated that this type of particle causes a certain fibrillar reaction, but that the progressive tendency may be slight. The weight of the lungs was significantly higher than in the controls and in animals given titanium oxide or glass wool at all times of observation, but only at the later observations with regard to the animals given iron silicate and olivine. A parallel development occurred with regard to the collagen content of the lungs following the administration of P125.