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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Public available literature without indication of guideline and GLP, only basic information available

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1990

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Public avaialble literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium hypochlorite
EC Number:
231-668-3
EC Name:
Sodium hypochlorite
Cas Number:
7681-52-9
Molecular formula:
ClO.Na
IUPAC Name:
sodium hypochlorite
Details on test material:
sodium hypochlorite

Test animals

Species:
mouse

Administration / exposure

Route of administration:
other: inhalation

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
other: RD50
Effect level:
4.1 ppm
Remarks on result:
other: based on free chlorine

Any other information on results incl. tables

The RD50 for an atmosphere of chlorine has been estimated as 6.7 ppm and an atmosphere of sodium hypochlorite (based on free chlorine) as 4.1 ppm. The similarity of the results show that the irritancy of the sodium hypochlorite is associated with the chlorine content of the material. This test measures only respiratory ( sensory ) irritancy and does not take into account other forms of toxicity.

Applicant's summary and conclusion

Executive summary:

The RD50 for an atmosphere of chlorine has been estimated as 6.7 ppm and an atmosphere of sodium hypochlorite (based on free chlorine) as 4.1 ppm. The similarity of the results show that the irritancy of the sodium hypochlorite is associated with the chlorine content of the material. This test measures only respiratory ( sensory ) irritancy and does not take into account other forms of toxicity.

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