Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 231-668-3 | CAS number: 7681-52-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation
- Remarks:
- other: in vivo / in vitro
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Public available literature without indication of guideline and GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 984
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Public avaialble literature. No guideline indicated. For details on method see materials and methods section in IUCLID5 dossier.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Sodium hypochlorite
- EC Number:
- 231-668-3
- EC Name:
- Sodium hypochlorite
- Cas Number:
- 7681-52-9
- Molecular formula:
- ClO.Na
- IUPAC Name:
- sodium hypochlorite
- Details on test material:
- sodium hypochlorite
Constituent 1
Test animals / tissue source
- Species:
- other: no data
Results and discussion
Any other information on results incl. tables
For sodium hypoclorite a severe ocular irritancy was reported. Highest tolerated (mM) dose was in Mouse 3T3, in Hamster CH V79, in Rabbit Cornea, in Human HepG2 and in Mouse RAW 264.7 cells.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information
- Executive summary:
- MATERIALS
AND METHODS:
A short-term cytotoxicity assay and a supplementary colony forming assay were used for screening and range finding of toxic concentrations of test agents. Sodium hypochlorite was tested among other substances on several mammlian cell cultures of different organs and species of origin.
RESULTS AND DISCUSSION:
For sodium hypoclorite a severe ocular irritancy was reported. Highest tolerated (mM) dose was in Mouse 3T3,in Hamster CH V79, in Rabbit Cornea, in Human HepG2 and in Mouse RAW 264.7 cells.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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