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EC number: 215-160-9 | CAS number: 1308-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 25/8/1988-8/9/1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 988
- Report date:
- 1988
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Chromium (III) oxide
- EC Number:
- 215-160-9
- EC Name:
- Chromium (III) oxide
- Cas Number:
- 1308-38-9
- Molecular formula:
- Cr2O3
- IUPAC Name:
- chromium (III) oxide
- Test material form:
- solid: particulate/powder
- Details on test material:
- The test material: Chromoxyd Dyko
- State of aggregation: green powder
- pH: 7 - 8
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: storage at room temperature
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen
- Females nulliparous and non-pregnant: yes
- Age at study initiation: males: ca. 9 weeks; females ca. 14 weeks
- Weight at study initiation(mean): males: 175 g: females: 172 g
- Fasting period before study: ca. 16 hours before test item administration and up to 4 hours after test item administration food was withdrawn.
- Housing: five animals/cage; Macrolon cage Typ III with dustfree wood pelletes (manufacturer: Firma Ssniff, Soest/Westfalen)
- Diet (ad libitum, for exception please refer to "Fasting period before study" above): "fixed-formula"- standard diet AltrominR1324 pellets (Manufacturer: Altromin GmbH, Lage)
- Water (ad libitum): drinking water
- Acclimation period: at least five days
ENVIRONMENTAL CONDITIONS
- Temperature: 22 ± 2 °C
- Relative humidity: 50 ± 10 %
- Air changes: ca. 10 air changes/h
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- DOSAGE PREPARATION:
The test material was suspended in water at room temperature. The test material was formulated prior to administration. A homogeneous mixture was accomplished by stirring.
Animals were dosed using a constant application volume of 20 mL/kg bw.
The application volume was calculated based in the individual body weight of the animals determined prior to test item application. - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 males / 5 females
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: on the day of the application, the animals were inspected several times and during the following 14-day observation period twice a day (once on weekends and holidays). The type, onset, duration and intensity of the clinical symptoms were recorded and any dead animals were removed. The time of death was recorded. At the end of the experiment animals were randomly selected for necropsy.
At application day, day 7 and at the end of the 14-day observation period, the surviving animals were individually weighed.
- Necropsy performed: yes, all deceased and surviving animals were macroscopically examined.. - Statistics:
- Statistical analysis not required
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occurred.
- Clinical signs:
- other: Clinical signs were limited to piloerection (one male and one female) and salivation (all animals) starting 15 minutes following dosing; signs had resolved within 8 hours.
- Gross pathology:
- There were no findings attributable to treatment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- LD50 (male rats) > 5000 mg/kg
According to the EC-Regulation 1272/2008 and subsequent regulations, the test item is not classified as acute toxic via the oral route.
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