Registration Dossier
Registration Dossier
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EC number: 257-098-5 | CAS number: 51274-00-1 This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77492.
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: case report
Data source
Reference
- Reference Type:
- publication
- Title:
- Contact dermatitis to yellow iron oxide.
- Author:
- Zugermann C
- Year:
- 1 985
- Bibliographic source:
- Contact Dermatitis 13, 107-109
Materials and methods
- Study type:
- clinical case study
- Endpoint addressed:
- skin sensitisation
Test material
- Reference substance name:
- 20344-49-4
- Cas Number:
- 20344-49-4
- IUPAC Name:
- 20344-49-4
- Reference substance name:
- Iron hydroxide oxide
- EC Number:
- 243-746-4
- EC Name:
- Iron hydroxide oxide
- IUPAC Name:
- 243-746-4
- Reference substance name:
- Iron hydroxide oxide
- IUPAC Name:
- Iron hydroxide oxide
Constituent 1
Constituent 2
Constituent 3
Method
- Subjects:
- 43-old non atopic white female
- Reason of exposure:
- intentional
- Exposure assessment:
- not specified
Results and discussion
Any other information on results incl. tables
The reaction to yellow iron oxide in this patient was significant while no reaction occurred in 10 normal controls.
No other case of yellow iron oxide dermatitis has been reported to occur as a result of its use as a pigment in an eyelid cosmetic.
It is unlikely that many additional cases such as the one reported here will occur, considering the large quantity of this material which thus far has been used without incident.
Applicant's summary and conclusion
- Executive summary:
- After epicutan patch testing, a 43-year-old non-atopic, white female with eyelid dermatitis was found to be positive to yellow iron oxid used as a dye in her mascara. Yellow iron oxide, also known as limonite (alpha-FeOOH) or yellow ochre, is a common cosmetic dye.
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