Registration Dossier
Registration Dossier
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EC number: 265-193-8 | CAS number: 64742-90-1 A complex combination of hydrocarbons obtained as the residual fraction from the distillation of the products of a steam cracking process (including steam cracking to produce ethylene). It consists predominantly of unsaturated hydrocarbons having carbon numbers predominantly greater than C14 and boiling above approximately 260°C (500°F). This stream is likely to contain 5 wt. % or more of 4- to 6-membered condensed ring aromatic hydrocarbons.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as unpublished report, no restrictions, fully adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- yes
- Remarks:
- occlusive dressing used
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Residues (petroleum), steam-cracked
- EC Number:
- 265-193-8
- EC Name:
- Residues (petroleum), steam-cracked
- Cas Number:
- 64742-90-1
- Molecular formula:
- UVCB substance
- IUPAC Name:
- Residues (petroleum), steam-cracked
- Reference substance name:
- carbon black oil
- IUPAC Name:
- carbon black oil
- Details on test material:
- - Name of test material (as cited in study report): carbon black oil
- Substance type: Mixture of high boiling aromatic hydrocarbons
- Physical state: dark brown liquid
- Analytical purity: not applicable
- Density : 1.03 - 1.11 g/cm3 at 288.7 K
- Boiling point (initial, average) : 428 K at 1 x 10E5 Pa
- Composition of test material: alicyclic- and arylbenzenes, bi- and tricyclic aromatic compounds, asphalthenes and other high boiling hydrocarbons.
Carbon Black Oil contains less than 3 weight-% of polycyclic aromatic hydrocarbons (PCA).
- Storage condition of test material: room temperature
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: Wistar outbred rats (Crl:Wl(WU)BR)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Breeding Centre for Laboratory Animals "Charles River Wiga GmbH", Sulzfeld, F.R. Germany
- Age at study initiation: approximately 10 weeks
- Weight at study initiation: 276-303 g for males, 174-197 g for females
- Fasting period before study: no
- Housing: 5/cage, sexes separately, in stainless steel cages with wire-screen bottom and front
- Diet: TNO Institute's cereal-based, open-formula basal diet for rats ad libitum (except overnight prior to dosing)
- Water: tap water ad libitum
- Acclimation period: approximately 5 weeks
ENVIRONMENTAL CONDITIONS
- Temperature: 20-24°C
- Humidity: 30-70%
- Air changes (per hr): 10
- Photoperiod: 12 hrs dark / 12 hrs light
IN-LIFE DATES: From: 31 July 1989 To: 15 August 1989
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- maize oil
- Details on dermal exposure:
- TEST SITE
- Area of exposure: dorsal and the ventral side and the flanks
- Type of wrap if used: a plastic film, which was secured by an elastic adhesive bandage (Tensoplast) around the trunk of the rats
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Yes with water
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 10 mL/kg bw
- Concentration (if solution): 20% w/v dilution in maize oil - Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: The rats were observed frequently for signs of intoxication during the first 4 post-treatment hours and later on, at least once daily. Individual body weights were recorded on days 0, 3, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: no mortality or evidence of toxicity at only dose tested
- Mortality:
- No mortality
- Clinical signs:
- other: No skin reactions were observed immediately after removal of the dressing and after 3 and 7 days. There were no clinical signs of intoxication.
- Gross pathology:
- No treatment-related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 to rats for Carbon Black Oil is greater than 2000 mg/kg bw.
- Executive summary:
- The acute dermal toxicity of Carbon black oil (CAS 64742-90-1) was investigated in groups of 5 male and 5 female rats. A single 24 hour application of 2000 mg/kg (20% w/v in maize oil at 10 mL/kg bw) was applied under an occlusive dressing and animals observed for 14 days for signs of toxicity and local irritation. There were no mortalities or evidence of toxicity or irritation. The acute dermal LD50 to rats for Carbon Black Oil is greater than 2000 mg/kg bw and no classification is warranted under Dir 67/548/EEC or GHS/CLP
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