Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

he systemic, nasal, and pulmonary responses to inhaled ACM that were observed in this study were similar to, or less than, that observed in rats similarly exposed to other inorganic particulates such as titanium dioxide (10 mg/m3 TiO2) or amorphous silica (50 mg/m3), respectively. It is significant that the ACM- induced pulmonary effects observed in this study were unlike those observed following exposure to a fibrogenic particulate such as crystalline silica (3 mg/m3) which results in significantly greater, chronic, neutrophilic inflammation and progressive pulmonary fibrotic lesions at exposure concentrations 3 to 20-fold lower than those used in this study. These data suggest that ACM has little or no inherent toxicity except that associated with inhalation of high concentrations of nontoxic, but irritating, inorganic particulates.

Key value for chemical safety assessment

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Dose descriptor:
60 mg/m³
Study duration:

Additional information

Justification for classification or non-classification