Registration Dossier
Registration Dossier
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EC number: 215-113-2 | CAS number: 1302-93-8
Endpoint summary
Administrative data
Description of key information
he systemic, nasal, and pulmonary responses to inhaled ACM that were observed in this study were similar to, or less than, that observed in rats similarly exposed to other inorganic particulates such as titanium dioxide (10 mg/m3 TiO2) or amorphous silica (50 mg/m3), respectively. It is significant that the ACM- induced pulmonary effects observed in this study were unlike those observed following exposure to a fibrogenic particulate such as crystalline silica (3 mg/m3) which results in significantly greater, chronic, neutrophilic inflammation and progressive pulmonary fibrotic lesions at exposure concentrations 3 to 20-fold lower than those used in this study. These data suggest that ACM has little or no inherent toxicity except that associated with inhalation of high concentrations of nontoxic, but irritating, inorganic particulates.
Key value for chemical safety assessment
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 60 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Additional information
Justification for classification or non-classification
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