Registration Dossier
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EC number: 200-661-7 | CAS number: 67-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
Description of key information
IC50 (germination) = 2104 mg/kg, 3 day, Lactuca sativa (Reynolds, 1977)
Key value for chemical safety assessment
- Short-term EC50 or LC50 for terrestrial plants:
- 2 104 mg/kg soil dw
Additional information
The toxicity of 2-propanol to the seed germination of the dicotyledon Lactuca sativa (garden lettuce) was assessed in a published non-guideline study that predates GLP requirements for ecotoxicity studies (Reynolds, 1977). This laboratory study used Great Lakes garden lettuce seeds sown in aluminium boxes (4.2 x 2.1 x 1.6 cm) with glass windows in the lids, containing 0.5% agar (8 mL) in which appropriate weights of 2-propanol were dissolved. Germination at 30ºC was recorded after 3 days. The results indicate that 35 mM of 2-propanol caused 50% inhibition of the germination of lettuce seeds. The molecular weight of 2-propanol is 60.1 g/mol and thus, the 50% inhibition value can be calculated to be 2104 mg/kg in the agar.
This study did not investigate any monocotyledon species and with only one dicotyledon species reported, it is difficult to establish an effect level that will be representative of the effects of 2-propanol on seedling emergence of higher plants.
Although the reliability of this study could not be sufficiently assessed, the result based on a 96 hours test supports that IPA also beyond 24h exposure does not pose significant hazard to invertebrates. Also, these results are consistent with observations on acute fish studies performed over 48 hours in a static test as well as in a flow through test, proving that the substance does not volatilize from test water within 48 hours.
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