Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 266-047-6 | CAS number: 65997-18-4 Frit is a mixture of inorganic chemical substances produced by rapidly quenching a molten, complex combination of materials, confining the chemical substances thus manufactured as nonmigratory components of glassy solid flakes or granules. This category includes all of the chemical substances specified below when they are intentionally manufactured in the production of frit. The primary members of this category are oxides of some or all of the elements listed below. Fluorides of these elements may also be included in combination with these primary substances.@Aluminum@Manganese@Antimony@Molybdenum@Arsenic@Neodymium@Barium@Nickel@Bismuth@Niobium@Boron@Phosphorus@Cadmium@Potassium@Calcium@Silicon@Cerium@Silver@Chromium@Sodium@Cobalt@Strontium@Copper@Tin@Gold@Titanium@Iron@Tungsten@Lanthanum@Vanadium@Lead@Zinc@Lithium@Zirconium@Magnesium
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 th May - 29 th July 2010
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, guideline study, available as an unpublished report, minor restrictions in design and/or reporting but otherwise adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
- Type of study / information:
- Bioaccessibility of 208Pb in the aqueous media: artificial gastric fluid , artificial lysosomal fluid, artificial sweat solution, PBS (phosphate buffered saline) and artificial interstitial fluid was determined in a 24 h test. Concentration measurements were made at 2 and 24h by ICP-MS. The limit of detection was 0.5 ug/L Pb. Loading rate 0.1 g/L.
was determined in a 2 hour test with a loading rate of 1g/50 ml (20 g/L) of test substance. A 24 hour test in similar media was also performed at a loading rate of 100 mg/50 ml (2000 mg/L).
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: OECD No. 29. Guidance document on transformation/dissolution of metals and metal compounds in aqueous media.
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: EEC guideline SANCO/3029/99 rev. 4 11/07/2000
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Details on test material:
- FC811
Constituent 1
Results and discussion
Any other information on results incl. tables
The amounts (µg/L) of 208Pb detected in media incubated with FC811 for 2 hours were: 69191 in artificial gastric fluid, 21876 in artificial lysosomal fluid, 32795 in artificial sweat solution, 25571 in PBS and 1036 in artificial interstitial fluid.The amounts (µg/L) of 208Pb detected in media incubated with FC811 for 24 hours were: 58373 in artificial gastric fluid, 4813 in artificial lysosomal fluid, 8126 in artificial sweat solution, 6985 in PBS and 1120 in artificial interstitial fluid.
Applicant's summary and conclusion
- Conclusions:
- The amounts (µg/L) of 208Pb detected in media incubated with FC811 for 2 hours were: 69191 in artificial gastric fluid, 21876 in artificial lysosomal fluid, 32795 in artificial sweat solution, 25571 in PBS and 1036 in artificial interstitial fluid.The amounts (µg/L) of 208Pb detected in media incubated with FC811 for 24 hours were: 58373 in artificial gastric fluid, 4813 in artificial lysosomal fluid, 8126 in artificial sweat solution, 6985 in PBS and 1120 in artificial interstitial fluid.
- Executive summary:
The amounts (µg/L) of 208Pb detected in media incubated with FC811 for 2 hours were: 69191 in artificial gastric fluid, 21876 in artificial lysosomal fluid, 32795 in artificial sweat solution, 25571 in PBS and 1036 in artificial interstitial fluid.The amounts (µg/L) of 208Pb detected in media incubated with FC811 for 24 hours were: 58373 in artificial gastric fluid, 4813 in artificial lysosomal fluid, 8126 in artificial sweat solution, 6985 in PBS and 1120 in artificial interstitial fluid. The highest concentrations of lead were found in artificial gastric fluid, artificial lysosomal fluid, artificial sweat solution and PBS after incubation with FC811 for 2 hours. The lead concentration in artificial interstitial fluid was marginally higher in media incubated for 24 h with FC811. This study (Pardo martinez, 2010) is considered reliable (2), it is a GLP compliant, guideline study, available as an unpublished report with minor restrictions in design and/or reporting but it is otherwise adequate for assessment.
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