Registration Dossier
Registration Dossier
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EC number: 205-582-1 | CAS number: 143-07-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOELR (21d) >= 1.3 mg/L (measured, TWA), RA from decanoic acid (CAS 334-48-5)
Key value for chemical safety assessment
Additional information
A study on the long-term toxicity of lauric acid (CAS 143 -07 -7) to aquatic invertebrates is available. This GLP study (Ministry of the Environment of Japan, 2001) was conducted according to OECD 211 and showed a NOEC (21 d) of 0.47 mg/L for Daphnia magna. Since severe deficiencies such as an invalid solvent control, instable test substance concentration, no defined dose-response curve and unknown fate of the test substance had been stated, the study was considered to be disregarded.
Therefore currently no reliable Daphnia Magna Reproduction study according to OECD 211 is available for lauric acid.
In the context of an ongoing test programme in cooperation with Fraunhofer Institute IME (FhG) in Schmallenberg/Germany in 2012 a new OECD 211 study with decanoic acid (CAS 334 -48 -5) was performed. The study was set up as limit test, in which the test item was prepared as WAF with a nominal loading of 5 mg/L and the medium was replaced daily. Samples were taken for chemical analysis from fresh and aged media during three representative 24 hours exposure periods per week. No immobilisation of daphnia occured throughout the test, neither the mean cummulative offspring was affected. Based on the measured time weighted average concentration (TWA), a NOELR >= 1.3 mg/L has been determined (corresponding to the nominal load of 5 mg/L).
This result is currently used as read across to chronic daphnia toxicity of C12 fatty acid (lauric acid). A detailed justification for the grouping of chemicals and read-across is provided in the Chemical Safety Report (CSR, see section 13 of the technical dossier).
A chronic toxicity study with lauric acid is in progress in order to overcome methodological deficiencies due to rapid decay of the test substance and to verify the hazard assessment.
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