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Toxicological information

Health surveillance data

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Administrative data

Endpoint:
health surveillance data
Type of information:
other:
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Occupational limit values have been established by the national health authorities of several industrialized countries. These limits are selected by experts in occupational health and, as such, can be considered valid.

Data source

Reference
Reference Type:
other: Agency document
Title:
Unnamed
Year:
2005

Materials and methods

Study type:
other: Occupational Exposure Limits
Endpoint addressed:
acute toxicity: inhalation
Test guideline
Qualifier:
no guideline required
Principles of method if other than guideline:
Review of basic scientific information in animal models, pharmacokinetics, human experience and human occupational poisonings.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium cyanide
EC Number:
205-599-4
EC Name:
Sodium cyanide
Cas Number:
143-33-9
Molecular formula:
CNNa
IUPAC Name:
sodium cyanide

Method

Type of population:
occupational
Ethical approval:
not applicable

Results and discussion

Results:
Occupational exposure limits (OELs) for the cyanide anion (CN-) derived from HCN, NaCN or KCN are: 1.0 mg/m3 for an 8-hour Time Weighted Average (TWA), and 5 mg/m3 for a 15-minute Short Term Exposure Limit (STEL). Molecular weight corrections for NaCN result in a value of 1.9 for the 8-hour value, and 9.4 for the 15-minute value. A skin notation applies to HCN, NaCN and KCN.

Applicant's summary and conclusion

Conclusions:
Occupational exposure limits (OELs) for the cyanide anion (CN-) range derived from HCN, NaCN or KCN are: 1.0 mg/m3 for an 8-hour Time Weighted Average (TWA), and 5 mg/m3 for a 15-minute Short Term Exposure Limit (STEL). Molecular weight corrections for NaCN result in a value of 1.9 mg/m3 for the 8-hour value, and 9.4 mg/m3 for the 15-minute value. A skin notation applies to HCN, NaCN and KCN.

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