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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1970

Materials and methods

Principles of method if other than guideline:
Method followed unknown, data from handbook
GLP compliance:
not specified
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Reference substance name:
Glycerides, C8-18 and C18-unsatd.
EC Number:
266-946-3
EC Name:
Glycerides, C8-18 and C18-unsatd.
Cas Number:
67701-28-4
Molecular formula:
Triglycerides containing a glycerol backbone esterified to fatty acids with a carbon chain length of C8-18 as well as unsaturated C18 fatty acids
IUPAC Name:
Tri(C8-18 and C18-unsatd. fatty acyl)glycerol
Details on test material:
- Name of test material (as cited in study report): Coconut oil (CAS N° 8001-31-8, EC N° 232-282-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18 and C18-unsatd.’


Method

Target gene:
No data
Species / strain
Species / strain / cell type:
S. typhimurium, other: strains not reported
Details on mammalian cell type (if applicable):
Not applicable
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified
Metabolic activation system:
no data
Test concentrations with justification for top dose:
5000 µg/plate
Vehicle / solvent:
No data
Controls
Untreated negative controls:
not specified
Negative solvent / vehicle controls:
not specified
True negative controls:
not specified
Positive controls:
not specified
Positive control substance:
not specified
Details on test system and experimental conditions:
No data
Evaluation criteria:
No data
Statistics:
No data

Results and discussion

Test results
Key result
Species / strain:
S. typhimurium, other: strains not reported
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified

Applicant's summary and conclusion

Conclusions:
The test substance was found to be non-mutagenic in Salmonella typhimurium reverse mutation
assay.
Executive summary:

A study was conducted to determine the mutagenicity potential of ‘glycerides, C8 -18 and C18 -unsatd.’ (as coconut oil) according to an unspecified method.

Under the study conditions, the substance was found to be non-mutagenic in Salmonella typhimurium reverse mutation assay at a concentration of 5,000 μg/plate (Biotech Index, 1970).