Registration Dossier
Registration Dossier
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EC number: 272-911-3 | CAS number: 68920-03-6 A complex combination obtained by steam distillation of C16-18 and C18-unsatd. glycerides followed by condensation of the steam.
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- Not available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary literature source (documentation insufficient for assessment), but used in the Cosmetic Ingredient Review (CIR) assessment report
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Principles of method if other than guideline:
- Single dose of fully hydrogenated coconut oil was applied dermally to guinea pigs and animals observed for 7 d.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- yes
Test material
- Reference substance name:
- 'Glycerides, C8-18 and C18-unsatd.'
- IUPAC Name:
- 'Glycerides, C8-18 and C18-unsatd.'
- Reference substance name:
- Glycerides, C8-18 and C18-unsatd.
- EC Number:
- 266-946-3
- EC Name:
- Glycerides, C8-18 and C18-unsatd.
- IUPAC Name:
- 266-946-3
- Reference substance name:
- 67701-28-4
- Cas Number:
- 67701-28-4
- IUPAC Name:
- 67701-28-4
- Details on test material:
- - Name of test material (as cited in study report): Fully hydrogenated coconut oil (CAS N° 84836-98-6, EC N° 284-283-8); under the SDA nomenclature, the name of this substance is ‘Glycerides, C8-18, C18-unsatd.’
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- No data
- Duration of exposure:
- Single dermal application
- Doses:
- 3,000 mg/kg bw
- No. of animals per sex per dose:
- 12
- Control animals:
- not specified
- Details on study design:
- No data
- Statistics:
- No data
Results and discussion
- Preliminary study:
- No data
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD0
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality during 7 d observation period
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under test conditions, the LD0 of of test substance in guinea pig was found to be 3,000 mg/kg bw.
- Executive summary:
In an acute dermal toxicity study, undiluted 'glycerides, C8-18 and C18-unsatd.' (in the form of fully hydrogenated coconut oil) was applied at a dose of 3,000 mg/kg bw to the skin of 12 guinea pigs.
No deaths occurred during the 7 d observation period.
Under test conditions, the LD0 of test substance was found to be 3,000 mg/kg bw.
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