Registration Dossier
Registration Dossier
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EC number: 200-877-1 | CAS number: 75-54-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
Additional information
There are no reliable investigations into the potential for dichloro(methyl)silane to have effects on fertility, so good quality data from DMSD have been used to fill the data gap. This substance is a close structural analogue of the hydrolysis product of dichloromethylsilane, methylsilanediol.
Short description of key information:
The are no data regarding the potential for the test substance to have adverse effects on fertility, therefore data for a related substance, dimethylsilanediol (DMSD, CAS 1066-42-8), have been used to read-across. In this OECD 422 study (Dow Corning Corporation, 2009), Sprague-Dawley rats were treated by oral gavage. No advserse effects were observed. As has been demonstrated by the acute toxicity and irritation/corrosion data, there would also be corrosive local effects from HCl if dichloro(methyl)silane were to be administered. There are no fertility data for the inhalation or dermal routes.
Effects on developmental toxicity
Description of key information
The are no data regarding the potential for the test substance to have adverse effects on development, therefore data from the hydrolysis product, dimethylsilanediol (DMSD, CAS 1066-42-8) have been used to read-across. In this OECD 422 study (Dow Corning Corporation, 2009), Sprague-Dawley rats were treated by oral gavage. No advserse effects were observed. As has been demonstrated by the acute toxicity and irritation/corrosion data, there would also be corrosive local effects from HCl if dichloro(methyl)silane were to be administered. There are no developmental toxicity data for the inhalation or dermal routes.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 500 mg/kg bw/day
Additional information
There are no reliable investigations into the potential for dichloro(methyl)silane to have effects on development, so good quality data from DMSD have been used to fill the data gap.
Justification for classification or non-classification
The available read-across study on DMSD did not reveal any effects on fertility or development of rats, therefore suggesting that there is no justification to classify dichloro(methyl)silane for reproductive and developmental toxicity.
The other hydrolysis product, hydrogen chloride, has no known reproductive or developmental toxicity effects.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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