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Diss Factsheets
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EC number: 200-589-6 | CAS number: 64-67-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- No data available
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The method used is similar to the acute standard method but the method and the results are poorly described.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range finding toxicity data, list III
- Author:
- Smyth HF, Carpenter CP, Weil CS
- Year:
- 1 949
- Bibliographic source:
- J Ind Hyg Tox 31: 60-61
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No guideline available at the date of the study. Method used is the standard acute method. More details on the method are given in previous publications. These details have been added hereafter.
The publications are:
Smyth & Carpenter (1944): The place of the range-finding test in the industrial toxicology laboratory. J Ind Hyg Tox 26: 269-273
Smyth & Carpenter (1948): Further experience with the range finding test in the industrial toxicology laboratory. J Ind Hyg Tox 30: 63-68 - GLP compliance:
- no
- Remarks:
- Study made before the GLP creation
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diethyl sulphate
- EC Number:
- 200-589-6
- EC Name:
- Diethyl sulphate
- Cas Number:
- 64-67-5
- Molecular formula:
- C4H10O4S
- IUPAC Name:
- diethyl sulfate
- Details on test material:
- No data available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No further information
TEST ANIMALS
- Source: no data
- Age at study initiation: no data
- Weight at study initiation: 90-120 g
- Fasting period before study: none
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
no data
IN-LIFE DATES: no data
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- No data
- Doses:
- 4 doses in geometrical series, no further information
- No. of animals per sex per dose:
- 5 animals per doses but no data on sex
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- LD50 determined using the Thompson method
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 880 mg/kg bw
- 95% CL:
- 760 - 1 010
- Mortality:
- No data
- Clinical signs:
- other: No data
- Gross pathology:
- No data
- Other findings:
- No data
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- According to these results, DES is considered as harmful by ingestion
- Executive summary:
Oral LD50 of DES has been determined in rats using 4 doses administrated to groups of 5 non fasted animals.
The LD 50 is 880 mg/kg (760 -1010).
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