Hydrocarbons, C10-C13, aromatics, <1% naphthalene

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species: fish

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

Standard bioaccumulation studies are not applicable to petroleum UVCB substances, therefore in accordance with Annex XI Section 1.3 testing is not scientifically necessary and the endpoint has been fulfilled using QSAR calculations for relevant constituents. Full justifications for this QSAR are presented in 'Attached justification as well as in 'Overall remarks and attachments'' section'. In brief these are justified because:
- the results are obtained from a QSAR model whose scientific validity has been established
- petroleum substances fall within the applicability domain of the QSAR model
- results are adequate for the purposes of risk assessment
- adequate and reliable documentation is provided

Qualifier:

no guideline required

Principles of method if other than guideline:

- Software tool(s) used including version: EPISuite v4.10
- Model(s) used: BCFBAF v3.01
- Model description: see field 'Attached justification'
- Justification of QSAR prediction, see field 'Attached justification

GLP compliance:

not specified

Remarks:

BCFBAF model

Key result

Type:

BCF

Value:

ca. 69.9 L/kg

Basis:

whole body w.w.

Calculation basis:

steady state

Conclusions:

BCF for Hydrocarbons, C11 -C15, aromatics, <1% Naphthalene, CAS No. 64742-94-5 is 69.9 L/kg wet-wt

Executive summary:

Standard bioaccumulation studies are not applicable to petroleum UVCB substances, therefore in accordance with Annex XI Section 1.3 testing is not scientifically necessary and the endpoint has been fulfilled using QSAR calculations for relevant constituents based on BCFBAF v3.01. Full justifications for this QSAR are presented in 'Attached justification' as well as in Overall remarks, attachements section ''Attached full study reporrt''. In brief these are justified because:

- the results are obtained from a QSAR model whose scientific validity has been established

- petroleum substances fall within the applicability domain of the QSAR model

- results are adequate for the purposes of risk assessment

BCF for Hydrocarbons, C11-C15, aromatics, <1% Naphthalene is 69.9 L/kg wet-wt (see Results and discussion section, Bioaccumulation factor).

Description of key information

Standard bioaccumulation studies are not applicable to petroleum UVCB substances, therefore in accordance with Annex XI Section 1.3 testing is not scientifically necessary and the endpoint has been fulfilled using QSAR calculations for relevant constituents based on BCFBAF v3.01. Full justifications for this QSAR are presented in 'Attached justification' as well as in Overall remarks, attachements section ''Attached full study reporrt''. In brief these are justified because:

- the results are obtained from a QSAR model whose scientific validity has been established

- petroleum substances fall within the applicability domain of the QSAR model

- results are adequate for the purposes of risk assessment

BCF for Hydrocarbons, C11-C15, aromatics, <1% Naphthalene is 69.9 L/kg wet-wt.

Key value for chemical safety assessment

BCF (aquatic species):

69.9 L/kg ww