Triphenyl phosphite

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Comparable to OECD 402, except this limit test used 3 animals/sex rather than 5/sex as recommended by the OECD guideline.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

GLP compliance:

yes

Test type:

other: Data needed for CSR report

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Triphenyl phosphate

EC Number:

204-112-2

EC Name:

Triphenyl phosphate

Cas Number:

115-86-6

Molecular formula:

C18-H15-O4-P

IUPAC Name:

triphenyl phosphate

Constituent 2

Reference substance name:

Triphenyl phosphite

EC Number:

202-908-4

EC Name:

Triphenyl phosphite

Cas Number:

101-02-0

Molecular formula:

C18H15O3P

IUPAC Name:

triphenyl phosphite

Details on test material:

- Name of test material (as cited in study report): Triphenyl phosphite
- Commercial purity: > 97% (Phosphorus content = 10.0 %)
- Lot/batch No.: TPPx-Z18-04080A
- Supplier: Borg Warner Company, Parkersburg, WV

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 2.0 and 3.0 kg
- Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR, Part 3.

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Area of exposure: All animals had their backs clipped free of hair 24 hours prior to testing and had their backs abraded prior to dosing.
- Type of wrap if used: large gauze patches and an impervious material was wrapped around the trunk of each animal.

REMOVAL OF TEST SUBSTANCE
- The dressings were removed after 24 hours and any excess material was removed.

Duration of exposure:

24 hours

Doses:

5.0 g/kg body weight. The sample was dosed as supplied (described as a colorless to straw-colored liquid).

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 21 days
- Frequency of observations and weighing: The animals were observed for a 21-day period for signs of toxicity and mortality.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 - < 5 other: g/kg

Mortality:

At 2 g/kg, no animals died. At a dose of 5 g/kg, all three males and females died. Deaths occurred over approximately 2-3 days after dosing.

Clinical signs:

other: After 5-6 hours, the animals appeared cold, and lethargic. They became semi-comatose after 18 hours. At 2 g/kg, there were no remarkable findings, except for substantial skin irritation lasting over several days.

Gross pathology:

Gross pathological examination revealed no remarkable findings.

Applicant's summary and conclusion

Interpretation of results:

study cannot be used for classification

Remarks:

Migrated information

Conclusions:

LD50 (rabbit) > 2 g/kg bw. TPP is not classifiably as to acute dermal toxicity.

Executive summary:

LD50 (rabbit) > 2 g/kg bw. TPP is not classifiably as to acute dermal toxicity.