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EC number: 202-908-4 | CAS number: 101-02-0
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Comparable to OECD 402, except this limit test used 3 animals/sex rather than 5/sex as recommended by the OECD guideline.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes
- Test type:
- other: Data needed for CSR report
- Limit test:
- yes
Test material
- Reference substance name:
- Triphenyl phosphate
- EC Number:
- 204-112-2
- EC Name:
- Triphenyl phosphate
- Cas Number:
- 115-86-6
- Molecular formula:
- C18-H15-O4-P
- IUPAC Name:
- triphenyl phosphate
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Details on test material:
- - Name of test material (as cited in study report): Triphenyl phosphite
- Commercial purity: > 97% (Phosphorus content = 10.0 %)
- Lot/batch No.: TPPx-Z18-04080A
- Supplier: Borg Warner Company, Parkersburg, WV
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 and 3.0 kg
- Housing: The animals were housed and maintained in compliance with the Animal Welfare Act (Pub. L-94-279) 9 CFR, Part 3.
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: All animals had their backs clipped free of hair 24 hours prior to testing and had their backs abraded prior to dosing.
- Type of wrap if used: large gauze patches and an impervious material was wrapped around the trunk of each animal.
REMOVAL OF TEST SUBSTANCE
- The dressings were removed after 24 hours and any excess material was removed. - Duration of exposure:
- 24 hours
- Doses:
- 5.0 g/kg body weight. The sample was dosed as supplied (described as a colorless to straw-colored liquid).
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 21 days
- Frequency of observations and weighing: The animals were observed for a 21-day period for signs of toxicity and mortality.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 - < 5 other: g/kg
- Mortality:
- At 2 g/kg, no animals died. At a dose of 5 g/kg, all three males and females died. Deaths occurred over approximately 2-3 days after dosing.
- Clinical signs:
- other: After 5-6 hours, the animals appeared cold, and lethargic. They became semi-comatose after 18 hours. At 2 g/kg, there were no remarkable findings, except for substantial skin irritation lasting over several days.
- Gross pathology:
- Gross pathological examination revealed no remarkable findings.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Remarks:
- Migrated information
- Conclusions:
- LD50 (rabbit) > 2 g/kg bw. TPP is not classifiably as to acute dermal toxicity.
- Executive summary:
LD50 (rabbit) > 2 g/kg bw. TPP is not classifiably as to acute dermal toxicity.
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