Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-908-4 | CAS number: 101-02-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1981
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EPA OTS 798.4470 (Acute Dermal Irritation)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Triphenyl phosphite
- EC Number:
- 202-908-4
- EC Name:
- Triphenyl phosphite
- Cas Number:
- 101-02-0
- Molecular formula:
- C18H15O3P
- IUPAC Name:
- triphenyl phosphite
- Details on test material:
- Lot # TPPX-Z18-04080A (Borg-Warner)
Constituent 1
Test animals
- Species:
- guinea pig
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: 10% w/v in Mineral Spirits
- Controls:
- no
- Amount / concentration applied:
- The test substance was in a suspension (10 % w/v) in Mineral Spirits.
- Duration of treatment / exposure:
- 24 hr application to skin, followed by 24 hr rest. Repeated for 10 applications.
- Observation period:
- 24 and 48 hrs after challenge, which followed 2 week rest period after cycle of 10 applications (20 days)
- Number of animals:
- 10 male
- Details on study design:
- Exposure to skin for 24 hrs, followed by 24 hr rest period, repeated for 10 applications. A two-week rest period followed the tenth skin application after which the skin was challenged and observed for 24 and 48 hours.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 1
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 0.4
- Max. score:
- 1
- Reversibility:
- other: erthyma disappeared in more than half of the animals within 24 hrs, no information about longer follow-up period
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48 h
- Score:
- 0
- Max. score:
- 0
- Remarks on result:
- other: No signs of edema in any of the animals.
- Irritant / corrosive response data:
- Full individual animal data are provided in the attached table.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- The results of this study show only slight irritation (mean PDII of 1 at 24 hrs and a mean PDII of 0.4 at 48 hrs) after 10 repeated 24 hr applications to the skin and a subsequent challenge after a 2 week rest period.
- Executive summary:
The results indicate that TPP is slightly irritating to the skin and not a skin sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
