Registration Dossier
Registration Dossier
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EC number: 235-921-9 | CAS number: 13048-33-4
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- A patch test with a series of 28 (meth-)acrylates was used to test patients for allergic contact dermatitis caused by these substances. 1,6-Hexanedioldiacrylate (HDDA) was one out of the 28 substances tested. However, no detailed data for HDDA were reported and previous exposure to HDDA is highly unlikely at least for the 4 dermatitis cases described.
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensitization to patch test acrylates
- Author:
- Kanerva L, Estlander T, Jolanki R
- Year:
- 1 988
- Bibliographic source:
- Contact Dermatitis 18: 10-15
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Patients with contact dermatitis were tested for sensitization of 28 commercial (meth-)acrylates using the Finn-chamber method (Contact dermatitis 1: 48-52, 1975) with an occlusion time of 24 hours. After removal of the test substance at least 3 readings were made.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Hexamethylene diacrylate
- EC Number:
- 235-921-9
- EC Name:
- Hexamethylene diacrylate
- Cas Number:
- 13048-33-4
- Molecular formula:
- C12H18O4
- IUPAC Name:
- hexane-1,6-diyl bisacrylate
- Details on test material:
- - Name of test material (as cited in study report): 1,6-hexanediol diacrylate
- Analytical purity: no data given
Constituent 1
Method
- Type of population:
- occupational
- Controls:
- no controls
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Finn chamber
- Vehicle / solvent: petrolatum
- Concentrations: 0.1 % (w/w); 0.0044 M
- Testing/scoring schedule: exposure of the test material for 24 h under occlusive conditions, removal of the test substance, readings after removal and 24 h, 48 h, and 96-120 h after removal (at least 3 readings) by a dermatologist.
Results and discussion
- Results of examinations:
- 12 of 24 patients showed no reaction to the (meth-)acrylate series. 3 were found to have a relevant allergic reaction and were diagnosed as having an occupational allergic contact dermatitis to acrylates. 9 patients showed a slight irritation at the 24 h and 48 h readings, sometimes also at 72-96 h, three of these were sensitized. No detailled information was given regarding reactions to HDDA.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
