Registration Dossier
Registration Dossier
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EC number: 283-482-7 | CAS number: 84650-02-2 A complex combination of hydrocarbons obtained by the distillation of coal tar. It consists of hydrocarbons having carbon numbers primarily in the range of C4 to C10 and distilling in the approximate range of 80°C to 160°C (175°F to 320°F).
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The main components of light oil listed below gave no evidence of an allergic potential in experimental animals or humans.
They are not classified for skin sensitising potential. Xylene, although found positive in the LLNA assay, is not considered to be skin sensitiser in humans, the LLNA finding interpreted in terms of false positive (Basketter et al. 1999; Ehling et al. 2005).
Components in CCSG-Composite sample No. 2, Light oil; ATE-No. 10438
Ingredient
CAS-No.
Concentration [%]
Benzene
71-43-2
32-36
Toluene
108-88-3
20-21
Xylenes
1330-20-7
11.3-13.4
Et-Benzene
100-41-4
2.4-2.9
Styrene
100-42-5
3.2-3.6
Naphthalene
91-20-3
1.6-1.8
Indene
95-13-6
8-11
References:
Basketter, D.A.; Lea, L.J.; Cooper, K.; et al. 1999: Threshold for classification as a skin sensitiser in the local lymph node assay: a statistical evaluation.
Food and Chemical Toxicology, 37, 1167-1174
Ehling, G.; Hecht, M.; Heusener, A.; Huesler, J.; Gamer, A.O.; et al. 2005: An European inter-laboratory validation of alternative endpoints of
the murine local lymph node assay: second round. Toxicology, 212, 69 -79
Justification for classification or non-classification
As the key components of light oil are not classifed and have provided no evidence for a sensitising potential, It is concluded that the sensitising potential of light oil - if existing at all - is negligible. Hence, no classification is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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