Benzyl acetate

Bioaccumulation: aquatic / sediment

Link to relevant study record(s)

Reference

Endpoint:

bioaccumulation in aquatic species, other

Type of information:

calculation (if not (Q)SAR)

Remarks:

Estimated by calculation

Adequacy of study:

key study

Study period:

1982

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

This data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained. This handbook is well recognised and reliable.

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to other study

Qualifier:

no guideline required

Principles of method if other than guideline:

This data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained.

GLP compliance:

no

Remarks:

Not required

Radiolabelling:

no

Details on sampling:

Not relevant

Vehicle:

no

Details on preparation of test solutions, spiked fish food or sediment:

Not relevant

Test organisms (species):

other: Please see below

Details on test organisms:

Calculations are based on the following species: Fathead minnow, Bluegill sunfish, Rainbow trout and Mosquito fish

Route of exposure:

aqueous

Test type:

flow-through

Water / sediment media type:

not specified

Hardness:

Estimation by Calculation

Test temperature:

Estimation by Calculation

pH:

Estimation by Calculation

Dissolved oxygen:

Estimation by Calculation

TOC:

Estimation by Calculation

Salinity:

Estimation by Calculation

Details on test conditions:

Estimation by Calculation

Nominal and measured concentrations:

Estimation by Calculation

Reference substance (positive control):

not required

Remarks:

Estimation by Calculation

Details on estimation of bioconcentration:

BASIS FOR CALCULATION OF BCF
log Kow = 1.96 (Sangster, 1989)
Equation: Log BCF = 0.76 Log Kow - 0.23 (Equation no 5.2 - Handbook of Chemical Estimation Methods)
Applicable range of Kow = 7.9 to 8100000

Equation gives Log BCF = 8

Type:

BCF

Value:

8 dimensionless

Basis:

not specified

Details on kinetic parameters:

Please see Table 1 for full calculation

Metabolites:

Not relevant

Results with reference substance (positive control):

Not relevant

Details on results:

Please see Table 1 for full calculation

Reported statistics:

Please see Table 1 for full calculation

Table 1: results

Molecular Weight

Log K(ow)

Log (l/s)

l/s (l/mol)

S (mol/L)

S (mg/L)

Log BCF calc.

BCF

Bioaccumulation Significant?

S measured mg/L

Vp mmHg at 20°C

VOC defined as vp >0.076 mm Hg

HLC calc Pa m3/mol

HLC Quoted/measured Pa m3/mol

Ex Croner Env

LogKoc calc

Koc calc

Koc quoted/measured

Interpretation of Koc

Log Koc calc

Koc calc

138

1.96

0.99

9.76

1.02E-01

14142

0.90

8

N

2660

0.12

Y

0.8

M

1.39

25

250 (Tessenderlo)

M

1.8

57

 

Validity criteria fulfilled:

not applicable

Remarks:

Estimation by calculation

Conclusions:

The log Kow value of Benzyl acetate is 1.96 (Sangster, 1989). The logKow is below the trigger of 3 therefore the substance is not expected to bioaccumulate in living organisms.

Executive summary:

The logKow value of Benzyl acetate was found to be 1.96 (Sangster, 1989). The logKow is below the trigger of 3 therefore the substance is not expected to bioaccumulate in living organisms. According to Column 2 of Annex IX of the REACH regulation, no bioaccumulation study is required if the logKow is below the trigger of 3.

However, data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained.

Using the above logKow figure, a BCF was derived using the Handbook of Chemical Property Estimation Methods.The BCF was found to be 8. According to the guidance on information requirements and chemical safety assessment part B, Benzyl acetate is not considered to be hazardous as the BCF is below 10.

Description of key information

The log Kow value of Benzyl acetate was found to be 1.96 (Sangster, 1989). The log Kow is below the trigger of 3 therefore the substance is not expected to bioaccumulate in living organisms. According to Column 2 of Annex IX of the REACH regulation, no bioaccumulation study is required if the log Kow is below the trigger of 3.

However, data was taken from the Handbook of Chemical Property Estimation Methods which describes the methods used for estimating bioconcentration factors in aquatic organisms. These methods are based on data from laboratory experiments that were designed to maintain relatively constant amounts of the chemical in the water environment, and where equilibrium concentrations of the chemical could be ascertained.

Using the above log Kow figure, a BCF was derived using the Handbook of Chemical Property Estimation Methods. The BCF was found to be 8. According to the guidance on information requirements and chemical safety assessment part B, Benzyl acetate is not considered to be hazardous as the BCF is below 10.

Key value for chemical safety assessment

BCF (aquatic species):

8 dimensionless