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EC number: 282-015-4 | CAS number: 84082-70-2 Extractives and their physically modified derivatives such as tinctures, concretes, absolutes, essential oils, oleoresins, terpenes, terpene-free fractions, distillates, residues, etc., obtained from Mentha piperita, Labiatae.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1965
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was not conducted according to an existing OECD guideline, and not under GLP, but acceptable basic information.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 965
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Male rats of the Wistar strain received 0.5, 1.0, and 2.0 ml/kg (451, 902, and 1804 mg/kg) of peppermint oil U.S.P., double distilled, intraperitoneally (ip). Twenty animals were used at each dosage, and the LD50 after 24 hr. was determined using the Reed-Muench method (Reed, L. J., and Muench, H., Am. J. Hyg., 27, 403, 1938). All animals in these studies were observed for a period of 30 days to include any possible latent effects.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Peppermint oil
- IUPAC Name:
- Peppermint oil
- Details on test material:
- - Name of test material (as cited in study report): Peppermint oil U.S.P. (double distilled)
- Composition of test material, percentage of components: ≥ 5% of esters, calculated as menthyl acetate, and ≥ 50% of total menthol, free and as esters.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.5, 1.0, and 2.0 ml/kg (451, 902, and 1804 mg/kg)
- No. of animals per sex per dose:
- 20
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 819 mg/kg bw
- Remarks on result:
- other: 24 hours
Any other information on results incl. tables
The animals receiving peppermint oil intraperitoneally exhibited brief stimulation, followed by depression beginning in approximately 15 minutes. Twitching, spastic convulsions, ataxia with hind limb paralysis, and abdominal contractions, very slowed respiration, and loss of righting reflex after 25 min. were all observed. Mortality after 24 hours: at 451 mg/kg: 5/20, at 902 mg/kg: 10/20 and at 1804 mg/kg: 19/20.
Applicant's summary and conclusion
- Conclusions:
- The LD50 of peppermint oil after IP injection was determined to be 819 ±126 mg/kg.
- Executive summary:
Male rats of the Wistar strain received 0.5, 1.0, and 2.0 ml/kg (451, 902, and 1804 mg/kg) of peppermint oil U.S.P., double distilled, intraperitoneally (ip). Twenty animals were used at each dosage, and the LD50 after 24 hr. was determined using the Reed-Muench method (Reed, L. J., and Muench, H., Am. J. Hyg., 27, 403, 1938). All animals in these studies were observed for a period of 30 days to include any possible latent effects.
The animals receiving peppermint oil intraperitoneally exhibited brief stimulation, followed by depression beginning in approximately 15 minutes. Twitching, spastic convulsions, ataxia with hind limb paralysis, and abdominal contractions, very slowed respiration, and loss of righting reflex after 25 minutes were all observed. Mortality after 24 hours: at 451 mg/kg: 5/20, at 902 mg/kg: 10/20 and at 1804 mg/kg: 19/20. The ip LD50 after 24 hr was 819 ±126 mg/kg.
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