Registration Dossier
Registration Dossier
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EC number: 241-774-1 | CAS number: 17796-82-6
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
According to the EC criteria for classification and labelling requirements for dangerous substances and mixtures the test substance does not have to be classified for carcinogenicity.
Additional information
No valid data on carcinogenicity studies in vitro is available.
Only one in vivo study for long-term toxicity of N-(cyclohexylthio)phtalimide in animals provided by U. S. EPA is available. Due to the lack of progression from benign to malignant lesions, the lack of proliferative lesions in males and negative results in genetic toxicology studies, the benign liver tumors were not considered to pose a significant human health risk. The NOAELs were 500 mg/kg/day for males, 500 mg/kg/day for females for malignant tumors and 50 mg/kg/day for females for benign tumors. The LOAEL was not determined for males and it was 150 mg/kg/day for benign tumors in females.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
