Registration Dossier
Registration Dossier
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EC number: 204-116-4 | CAS number: 115-95-7
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data available as short summary from a secondary source beeing cited in a peer-reviewed publication
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Acute toxicity studies in mice, rats and rabbits. Report to RIFM
- Author:
- Moreno OM
- Year:
- 1 972
- Bibliographic source:
- cited in: Linalyl acetate CAS 115-95-7 RIFM ID 138 FEMA 2536 RIFM - FEMA Database
- Reference Type:
- publication
- Title:
- A toxicologic and dermatologic assessment of linalool and related esters when used as fragrance ingredients
- Author:
- Bickers, D. et al.
- Year:
- 2 003
- Bibliographic source:
- Food and Chemical Toxicology, 41, (2003), 919–942
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity study in rabbits. Three rabbits were used. Observations were made for mortality and toxic effects for a period of 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Linalyl acetate
- EC Number:
- 204-116-4
- EC Name:
- Linalyl acetate
- Cas Number:
- 115-95-7
- Molecular formula:
- C12H20O2
- IUPAC Name:
- 1,5-dimethyl-1-vinylhex-4-en-1-yl acetate
- Details on test material:
- - Name of test material (as cited in study report): Linalyl acetate
- Other: Sample: HRB-03-1194
No further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Doses:
- 5000 mg/kg
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- no deaths recorded; (0/3)
Any other information on results incl. tables
5 g/kg no effects
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
