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EC number: 204-809-1 | CAS number: 126-86-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1971
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 971
- Report date:
- 1971
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guide to Precautionary Labeling of Hazardous Chemicals, Seventh Edition - 1970, published by the Manufacturing Chemist´s Association
- Deviations:
- no
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
Test material
- Reference substance name:
- 2,4,7,9-tetramethyldec-5-yne-4,7-diol
- EC Number:
- 204-809-1
- EC Name:
- 2,4,7,9-tetramethyldec-5-yne-4,7-diol
- Cas Number:
- 126-86-3
- Molecular formula:
- C14 H26 O2
- IUPAC Name:
- 2,4,7,9-tetramethyldec-5-yne-4,7-diol
- Details on test material:
- Sample# bl 1636
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- other
- Doses:
- 500 mg per kg of body weight
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 500 mg/kg bw
- Mortality:
- no mortality
- Gross pathology:
- Necropsy of all animals following sacrifice revealed at the end of the 14-day post-dose observation period, no gross pathological changes that could be attributed to administration were observed.
Any other information on results incl. tables
RS-Freetext:
All animals survived, showed no abnormal clinical signs and
gained weight. Gross necropsy did not reveal any test
material-related pathological changes.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The oral administration to rats of 500 mg of Surfynol 104 per kg of body weight resulted in no mortality.
Accordingly, the submitted test material is not considered a toxic material orally, under the definition set forth by the
Manufacturing Chemist´s Association. - Executive summary:
The oral administration to rats of 500 mg of Surfynol 104 per kg of body weight resulted in no mortality.
Accordingly, the submitted test material is not considered a toxic material orally, under the definition set forth by the
Manufacturing Chemist´s Association.
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