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Diss Factsheets
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EC number: 248-597-9 | CAS number: 27676-62-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
The substance is not readily biodegradable achieving 7% in 28 days. Due to high water insolubility (<0.04 mg/L), it is not possible to assess the potential for hydrolysis by testing. The substance is, however a stable organic molecule and is therefore, considered by assessment of structure and experience in use to hydrolyse in the environment.
The substance is considered to be very persistent in the environment were exposure to occur based on the known lack of biodegradability.
The bioconcentration factor (BCF) has been assessed by four separate techniques to provide for a weight of evidence. These data suggest a likely BCF ranging from 0.6 to 7.43 L/kg wet-wt.
The partition coefficient of the substance has been calculated using QSAR estimation based upon the SMILES code of the molecular structure US EPA KOWWIN v1.68 of the EPI Suite v4.1. Based upon structural fragmentation drawn from a database of >40,000 substance, the log Pow is estimated to be 15.18. The extremely high log Pow is likely to be due in part to the hydrophobic nature of the molecule.
Furthermore, assessment of the Toxicokinetic activity of the substance, based on a close structural analogue, conducted with a radioisotope demonstrates that 28% was located in the GI tract with the total remaining mass balance (71%) excreted in faeces.
Based on these data the substance is considered to be non-bioaccumulating.
Eco-toxicity studies:
Due to the substance being highly insoluble in water exposure to three aquatic species (algae, daphnia and fish) have been investigated at nominal concentrations. The toxicological examination on daphnia and algae provided an EC50 >100 mg/L and the results on a close structural analogue on fish produced an LC50 >1000 mg/L.
Mammalian toxicity studies:
The substance has been assess for genetic toxicity by three in vitro assays and one in vivo assay, with and without metabolic activation, all four studies demonstrated a lack of mutagenic response.
The Prenatal Developmental Toxicity produced a NOAEL >1000 mg/kg bw/day.
The 90-day toxicity feeding study achieved A NOAEL >1000 mg/kg bw/day with no significant dose-related effects detailed.
Considering the toxicological information the substance is not toxic.
The substance may pose a persistence (P) hazard but as the results produced no bioaccumulation (B) or toxicity (T) properties the substance cannot be considered as a PBT/vPvBT.
- Likely routes of exposure:
The substance is a powder of a particle size that is not breathable and is generally used in closed conditions.
The likely route of exposure to workers would be by dermal exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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