Registration Dossier

Administrative data

Description of key information

Skin irritation / corrosion: not irritant EU B.4
eye irritation: moderately irritant EUB.5
respiratory irriation: no data

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

key study (EU protocol B.4, GLP) indicates that SMCA is not a skin irritant

key study (EU protocol B.5, GLP) indicates that SMCA is a moderate eye irritant

no data on respiratory irritation


Effects on eye irritation: moderately irritating

Justification for classification or non-classification

Based on the available animal data and experience in humans SMCA need to be classified for irritation to eyes. The existing CLP ANNEX VI classification also indicates classification as a skin irritant.