Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 223-498-3 | CAS number: 3926-62-3
Endpoint summary
Administrative data
Description of key information
No direct information is available on clinical cases or poisoning incidents with SMCA. However, based on the fact that udner physiological conditions both SMCA and MCAA are completely ionized, with the chloroacetate ion as the active moiety, risk assessment is based on the oral toxicity data for MCAA. One case of oral consumption of MCAA is described
No relationship between estimated MCAA consumption from chlorinated drinking water and the occurence of hypospadia. Klimisch 4
clinical observation: negative for cross-allergy between ethylester of MCAA and MCAA itself.
Additional information
No relationship between occurence of hypospadia and maternal exposure to estimated drinking water contamination with haloacetic acids. In view of the serious limitations and confounders in this study, the negative result is meaningless.
Data from dermal contamination with MCAA is not applicable to SMCA in view of the much lower skin absorption.
The clinical case describing a fatality after xonsumption of ~75 ml MCAA is relevant for SMCA
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
