Registration Dossier
Registration Dossier
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EC number: 217-168-8 | CAS number: 1761-71-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- short-term repeated dose toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The original study was not obtained by the reviewer.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 954
- Report date:
- 1954
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Mice were administered substance by intraperitoneal injection daily for 5 days, at various doses, and toxicity was assessed.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'-methylenebis(cyclohexylamine)
- EC Number:
- 217-168-8
- EC Name:
- 4,4'-methylenebis(cyclohexylamine)
- Cas Number:
- 1761-71-3
- Molecular formula:
- C13H26N2
- IUPAC Name:
- 4,4'-methylenedicyclohexanamine
- Details on test material:
- CAS 1761-71-3 (cyclohexylamine,4'4-methylenebis-).
Material is a solid, approximately 50% trans-trans isomer
Constituent 1
Test animals
- Species:
- mouse
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 5 days
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
25, 50, 100 mg/kg bw
- Control animals:
- not specified
- Details on study design:
- Test was performed as a range-finding study for dose selection for a test of antineoplasic effects of the substance. Five animals per group were used, doses tested were 25, 50 and 100 mg/kg bw. Test substance (in oil) was administered i.p.
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Details on results:
- - In the highest dose group, all animals died shortly after the first or second injection. In the mid-dose group, two animals died
- These animals showed marked body weight loss
- The animals of the lowest dose group showed no symptoms
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
