Registration Dossier
Registration Dossier
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EC number: 231-748-8 | CAS number: 7719-09-7
Toxicity to reproduction
Administrative data
- Endpoint:
- toxicity to reproduction
- Adequacy of study:
- supporting study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- OECD SIDS HYDROGEN CHLORIDE CAS N°: 7647-01-0
- Author:
- OECD SIDS HYDROGEN CHLORIDE
- Year:
- 2 002
- Bibliographic source:
- UNEP PUBLICATIONS
Materials and methods
- Principles of method if other than guideline:
- OECD SIDS document; comprehensive evaulation of all available data.
Test material
- Reference substance name:
- Hydrogen chloride
- EC Number:
- 231-595-7
- EC Name:
- Hydrogen chloride
- Cas Number:
- 7647-01-0
- IUPAC Name:
- chloride
Constituent 1
Results and discussion
Overall reproductive toxicity
- Reproductive effects observed:
- not specified
Any other information on results incl. tables
No reliable studies have been reported regarding toxicity to reproduction and development in animals after oral, dermal or inhalation exposure to hydrogen chloride/hydrochloric acid. Because protons and chloride ions are normal constituents in the body fluid of animal species, low concentrations of hydrogen chloride gas/mist or solution do not seem to cause adverse effects to animals. In fact, the cells of gastric glands secrete hydrochloric acid into the cavity of the stomach and orally administered sulfuric acid, which results in pH change as well, did not cause developmental toxicity to laboratory animals. These facts indicate that hydrogen chloride/hydrochloric acid is not expected to have developmental toxicity. In addition, no effects on the gonads were observed in a good quality 90- day inhalation study up to 50 ppm.
Applicant's summary and conclusion
- Executive summary:
The following conclusion was drawn in the SIAR summary conclusion:
"No reliable studies have been reported regarding toxicity to reproduction and development in animals after oral, dermal or inhalation exposure to hydrogen chloride/hydrochloric acid. Because protons and chloride ions are normal constituents in the body fluid of animal species, low concentrations of hydrogen chloride gas/mist or solution do not seem to cause adverse effects to animals. In fact, the cells of gastric glands secrete hydrochloric acid into the cavity of the stomach and orally administered sulfuric acid, which results in pH change as well, did not cause developmental toxicity to laboratory animals. These facts indicate that hydrogen chloride/hydrochloric acid is not expected to have developmental toxicity. In addition, no effects on the gonads were observed in a good quality 90- day inhalation study up to 50 ppm."
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