Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Ueber Methaemoglobinaemie unter Mentholeinwirkung sowie erste Versuche mit dem Impedance-Pneumographen über die Beeinflussung der Atmung
- Author:
- Berger H, Hohenwallner W, Arakelian N
- Year:
- 1 967
- Bibliographic source:
- in Menthol and Menthol-containing external remedies, ed. Dost, F.H. and Leiber, B., page 120-134, Georg Thieme Verlag Stuttgart (1967)
Materials and methods
- Type of study / information:
- methaemoglobin bilding in vitro
- Principles of method if other than guideline:
- haemolysates of infantile erythrocytes were mixed with 50, 100, 200 and 500 gamma menthol
- GLP compliance:
- no
Test material
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
Constituent 1
Results and discussion
Any other information on results incl. tables
When haemolysates of infantile erythrocytes were mixed with 50, 100, 200 and 500 gamma menthol, the methaemoglobin content rose by up to 100 %, namely from 0.7% to 1.5%; these values values are absolutely within physiological limits.
Applicant's summary and conclusion
- Conclusions:
- When haemolysates of infantile erythrocytes were mixed with 50, 100, 200 and 500 gamma menthol, the methaemoglobin content rose by up to 100 %, namely from 0.7% to 1.5%; these values values are absolutely within physiological limits.
- Executive summary:
in vitro test:
when haemolysates of infantile erythrocytes were mixed with 50, 100, 200 and 500 gamma menthol, the
methaemoglobin content rose by up to 100 %, namely from 0.7 to 1.5%; these values are absolutely within physiological limits and this effect could be neutralized with vitamin C (test substance: unspecified isomer)
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