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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Ecotoxicological information

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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1989-02-01
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
yes
Principles of method if other than guideline:
- settled sludge was used instead of centrifuged sludge
- test substance was nor dissolved but distributed in the test medium
- sludge concentration in the test vessels was 1.9 g/L
GLP compliance:
not specified
Analytical monitoring:
no
Details on sampling:
Oxygen consumption per hour was measured using a ORION-Electrode Type 97-08 and ORION Microprocessor Ionalizer 901.
Vehicle:
no
Test organisms (species):
activated sludge of a predominantly domestic sewage
Details on inoculum:
activated sludge collected from sewage treatment plant in Reinach 3 days before testing
Test type:
static
Water media type:
freshwater
Limit test:
yes
Total exposure duration:
3 h
Test temperature:
20°C +-2
Nominal and measured concentrations:
nominal concentrations:
112,5 mg/L
117 mg/L
Reference substance (positive control):
yes
Remarks:
3,5-Dichlorophenol
Duration:
3 h
Dose descriptor:
other: IC 20
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
IC50
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
other: IC 80
Effect conc.:
> 100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Results with reference substance (positive control):
IC 50 13 mg/L
Validity criteria fulfilled:
yes
Conclusions:
The substance was shown to have no toxic effect to activated sludge.

Description of key information

The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.

Key value for chemical safety assessment

Additional information

According to regulation (EC) no 1907/2006, Annex XI, paragraph 1.5., substances whose physicochemical, toxicological and ecotoxicological properties are likely to be similar or follow a regular pattern as a result of structural similarity may be considered as a group, or "category" of substances. Environmental effects or environmental fate may be predicted from data for reference substance(s) within the group by interpolation to other substances in the group (read-across approach).

The analogue substance is a sterically hindered amine with functional groups that are almost identical to EC no. 41 -990 -0. Its physicochemical properties are similar and comparable to each other. Furthermore, both substances have similar environmental fates. Thus, the analogue substance is regarded as suitable for read across.