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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin corrosion: in vitro / ex vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
04 September 2012 - 13 September 2012
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Conducted according to an appropriate OECD guideline and under GLP.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2012
Report date:
2012

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 431 (In Vitro Skin Corrosion: Human Skin Model Test)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetrahydro-2-methylfuran
EC Number:
202-507-4
EC Name:
Tetrahydro-2-methylfuran
Cas Number:
96-47-9
Molecular formula:
C5H10O
IUPAC Name:
2-methyltetrahydrofuran
Test material form:
other: liquid
Details on test material:
- Name of test material (as cited in study report): tetrahydro-2-methylfuran

- Physical state: clear colourless liquid

- Storage condition of test material: room temperature in the dark under nitrogen

Test animals

Species:
other: n/a
Strain:
other: n/a
Details on test animals or test system and environmental conditions:
n/a

Test system

Type of coverage:
other: n/a
Preparation of test site:
other: n/a
Vehicle:
unchanged (no vehicle)
Controls:
other: positive control: glacial acetic acid, negative control: 0.9% w/v sodium chloride solution
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 50 microlitres
- Concentration (if solution): undiluted

Duration of treatment / exposure:
3, 60 and 240 minutes.
Observation period:
The tissues were incubated in MTT solution overnight after stopping treatment, which after optical density measurements were taken.
Number of animals:
Duplicate tissue/test condition
Details on study design:
See 'any other information on materials and methods'.

Results and discussion

In vitro

Resultsopen allclose all
Irritation / corrosion parameter:
other: other: relative mean viability
Value:
107.3
Remarks on result:
other:
Remarks:
Basis: mean. Time point: 3 minutes exposure . Reversibility: other: n/a. Remarks: Score expressed as a percentage. (migrated information)
Irritation / corrosion parameter:
other: other: relative mean viability
Value:
57.3
Remarks on result:
other:
Remarks:
Basis: mean. Time point: 60 minutes exposure. Reversibility: other: n/a. Remarks: Score expressed as a percentage. (migrated information)
Irritation / corrosion parameter:
other: other: relative mean viability
Value:
79.1
Remarks on result:
other:
Remarks:
Basis: mean. Time point: 240. Reversibility: other: n/a. Remarks: Score expressed as a percentage. (migrated information)

In vivo

Irritant / corrosive response data:
None reported.

Applicant's summary and conclusion

Interpretation of results:
other: Non-corrosive
Remarks:
Criteria used for interpretation of results: OECD GHS
Conclusions:
Tetrahydro-2-methylfuran was not considered to be corrosive to skin, as determined in an in vitro assay (EPISKIN) conducted in accordance with current OECD guideline and GLP.