Decanal

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

No data

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1962

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

1 day cuff method of Draize et al.

GLP compliance:

no

Remarks:

study predates GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Decanal

EC Number:

203-957-4

EC Name:

Decanal

Cas Number:

112-31-2

Molecular formula:

C10H20O

IUPAC Name:

decanal

Specific details on test material used for the study:

- Name of test material (as cited in study report): 1-Decanal (mixed isomers)
- Substance type: Aldehyde
- Physical state: No data
- Analytical purity: No data
- Impurities (identity and concentrations): No data
- Composition of test material, percentage of components: No data
- Isomers composition: No data
- Purity test date: No data
- Lot/batch No: No data
- Expiration date of the lot/batch: No data
- Stability under test conditions: No data
- Storage condition of test material: No data

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2.5 to 3.5 kg
- Fasting period before study: No data
- Housing: No data
- Diet (e.g. ad libitum): No data
- Water (e.g. ad libitum): No data
- Acclimation period: No data

ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data

Administration / exposure

Type of coverage:

occlusive

Vehicle:

unchanged (no vehicle)

Details on dermal exposure:

TEST SITE
- Fur removed from entire trunk by clipping
- Animals immobilised during 24 hr contact period

Doses:

Maximum dose 20 mL/kg

No. of animals per sex per dose:

4

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 d

Statistics:

Based on the mortality during the 14 d period, the most probable LD₅₀ value and its fiducial range was estimated using the method of Thompson using the Tables of Wiel. The limits, where appropriate, were calculated as ± 1.96 standard deviations.

Results and discussion

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

5.04 mL/kg bw

Based on:

test mat.

95% CL:

>= 3.78 - <= 6.82

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met

Conclusions:

The test substance was assessed for acute dermal toxicity using New Zealand white rabbits in a standard acute method. The LD50 was 5.04 mL/kg bodyweight.