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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

A literature study on acute oral  toxicity in male rats is available that resulted in an LD50 valu of 177 mg/kg. Due to the corrosive properties of the substance to skin and mucous membranes dermal studies were perfomed as they are not scientifically justified also from an animal protection poitn of view. The substance is classified according to Regulation EC 1272/2008 (CLP) as acute toxic category 3 by the oral, dermal and inhalation route. This is corroborated by some limited data base data on inhalation and dermal toxicity that are, however of limited reliability.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
177 mg/kg bw
Quality of whole database:
Literature value with sufficient documentation

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

A literature study on acute oral toxicity in male rats is available that resulted in an LD50 valu of 177 mg/kg. Due to the corrosive properties of the substance to skin and mucous membranes no inhalation and dermal studies were perfomed as they are not scientifically justified also from an animal protection poitn of view. The substance is classified according to Regulation EC 1272/2008 (CLP) as acute toxic category 3 by the oral, dermal and inhalation route. Some limited data base data are available indicating an LC50, inhal, rat 1 h exposure of >2 and < 200 mg/l and LD50, dermal rabbit of ca. 60 mg/kg bw, Lethal doses in rats after dermal exposure >100 but < 250 mg/kg bw,


Justification for selection of acute toxicity – oral endpoint
Mortality as specified in the acute toxicity determination

Justification for selection of acute toxicity – inhalation endpoint
Due to the corrosivity of the substance an inhalation study is not scientifially justified. Effects are drven by the local irritating and corrosive properties. Some limited data base data are available indicating an LC50, inhal, rat 1 h exposure of >2 and < 200 mg/l.

Justification for selection of acute toxicity – dermal endpoint
Due to the corrosivity of the substance an inhalation study is not scientifially justified. Effects are drven by the local irritating and corrosive properties. Some limited data base data are available indicating an LD50, dermal rabbit of ca. 60 mg/kg bw, and lethal doses in rats after dermal exposure >100 but < 250 mg/kg bw

Justification for classification or non-classification

A literature study on acute oral toxicity in male rats is available that resulted in an LD50 valu of 177 mg/kg. Due to the corrosive properties of the substance to skin and mucous membranes no inhalation and dermal studies were perfomed as they are not scientifically justified also from an animal protection poitn of view. The substance is classified according to Regulation EC 1272/2008 (CLP) as acute toxic category 3 by the oral, dermal and inhalation route. This is justified by the available oral data and the corrosivity of the test substance corroborated by data base data on dermal and inhalation toxicity of limited reliability.