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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
supporting study
Study period:
1996
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The result was obtained from a collection of reliable data which has been subject to peer-review and in which the original sources are traceable. This is a read across from Zinc distearate.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Final report of the safety assessment of lithium stearate, aluminium distearate, aluminium stearate, aluminium tristearate, ammonium stearate, calcium stearate, magnesium stearate, potassium stearate, sodium stearate, and zinc distearate.
Author:
Cosmetic Ingredient Review
Year:
1982
Bibliographic source:
J. Am. Coll. Toxicol. 1, 143-177. [as reported in the zinc distearate RAR 2008]
Reference Type:
secondary source
Title:
Zinc distearate RAR (2008). Risk Assessment Report zinc distearate (CAS 557-05-1) . Final Report, May 2008. European union risk assessment report for zinc distearate, volume 44.
Author:
ZINC RAR
Year:
2008
Report date:
2008

Materials and methods

Test guideline
Qualifier:
no guideline followed
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
Zinc distearate
EC Number:
209-151-9
EC Name:
Zinc distearate
Cas Number:
557-05-1
Molecular formula:
C18H36O2.1/2Zn
IUPAC Name:
zinc dioctadecanoate
Details on test material:
- Name of test material : zinc distearate
- Substance type: Organic
- Physical state: Solid

Test animals

Species:
rat
Strain:
other: Albino
Sex:
not specified

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
1 h
Concentrations:
200 mg/l
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 200 mg/L air
Based on:
test mat.
Exp. duration:
1 h
Mortality:
1/10 rats died during 2-wk. observation period. Material was considered non toxic by investigators.
Clinical signs:
other: No information
Body weight:
No information
Gross pathology:
No information

Any other information on results incl. tables

1/10 rats died within the 14 day observation period.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The substance Zinc distearate is not toxic by inhalation route
Executive summary:

The LC50 value of zinc distearate to rat is >200 mg/L air. The report was lacking in detail. The result is a read accross from zinc distearate (CAS 557-05-1).