Registration Dossier
Registration Dossier
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EC number: 201-553-2 | CAS number: 84-69-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, Non-guideline study. Available as a published report. Acceptable with restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
- Principles of method if other than guideline:
- Groups of 10 Male ICR mice were administered DIBP undiluted ip and observed 7 days for mortality. These were compared to a control who were administed with cornseed oil.
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Diisobutyl phthalate
- EC Number:
- 201-553-2
- EC Name:
- Diisobutyl phthalate
- Cas Number:
- 84-69-5
- Molecular formula:
- C16H22O4
- IUPAC Name:
- 1,2-bis(2-methylpropyl) benzene-1,2-dicarboxylate
- Details on test material:
- Supplied by Eastman Chemicals, Kingsport, Tennessee.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- 7 days
- No. of animals per sex per dose:
- 10 male mice per dose level
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 7 days
Control animals aministed cottonseed oil only.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 3.99 other: g/kg b.w.
- Based on:
- test mat.
- 95% CL:
- 3.91
Applicant's summary and conclusion
- Conclusions:
- The LD50 for DIBP was 3.99 g/kg. (95% Confidence Interval 3.91-4.08.)
- Executive summary:
This study was conducted prior to the implementation of OECD guidelines and GLP, but followed methods of the time and contains sufficient detail for assessment. It is considered suitable for use as a key study for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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